AKAP6 and PRKAR2A

Number of citations of the paper that reports this interaction (PMID 10413680)
46

Data Source:
HPRD (in vivo, in vitro)

		AKAP6	PRKAR2A
Gene Name		A kinase (PRKA) anchor protein 6	protein kinase, cAMP-dependent, regulatory, type II, alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion CAMP-dependent Protein Kinase Complex Membrane AMP-activated Protein Kinase Complex Extracellular Vesicular Exosome Ciliary Base
	Molecular Function	Protein Binding Adenylate Cyclase Binding Protein Complex Scaffold Protein Kinase A Regulatory Subunit Binding Protein Anchor Ion Channel Binding Protein Kinase A Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Phosphatase Type 2B Activity Intracellular Signal Transduction Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity	Renal Water Homeostasis Energy Reserve Metabolic Process Water Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways			Signaling by GPCR Ca-dependent events CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Integration of energy metabolism Phospholipase C-mediated cascade Signaling by FGFR in disease Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR DARPP-32 events Glucagon signaling in metabolic regulation Innate Immune System Signaling by PDGF PKA activation in glucagon signalling Calmodulin induced events Signalling by NGF DAP12 interactions PKA-mediated phosphorylation of CREB PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events PKA activation Factors involved in megakaryocyte development and platelet production Signaling by Overexpressed Wild-Type EGFR in Cancer Aquaporin-mediated transport Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 PKA-mediated phosphorylation of CREB Signaling by EGFR Downstream signal transduction Calmodulin induced events Signaling by Hedgehog PLC-gamma1 signalling Signaling by EGFR in Cancer PKA activation
Drugs
Diseases
GWAS		Anorexia nervosa ( 21079607) Economic and political preferences (environmentalism) ( 22566634) Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		7 interactors: CALM1 CDC5L DISC1 DTNBP1 PDE4D PRKAR2A RYR2	33 interactors: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP2 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CFTR EZR MAP2 MYCBPAP NBEA PJA2 PPP1CB PRKX RAB32 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1
Entrez ID		9472	5576
HPRD ID		05257	01484
Ensembl ID		ENSG00000151320	ENSG00000114302
Uniprot IDs		B2RP22 Q13023	P13861 Q9BUB1
PDB IDs			2IZX 2KYG
Enriched GO Terms of Interacting Partners?		Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Striated Muscle Contraction Intracellular Signal Transduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Heart Rate By Chemical Signal Regulation Of Cellular Localization Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Adrenergic Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Regulation Of Ion Homeostasis Regulation Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Heart Rate Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Catecholamine Stimulus Muscle Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Cation Channel Activity Muscle System Process Signaling Response To Organonitrogen Compound Cell Communication Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Negative Regulation Of Phosphorylation	Regulation Of Protein Kinase A Signaling Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Signaling Cellular Response To CAMP Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Communication Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Cellular Response To Stimulus Regulation Of Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Response To Stimulus Protein Localization Response To Purine-containing Compound Regulation Of Membrane Repolarization Regulation Of Signal Transduction Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity Positive Regulation Of Cation Channel Activity Cellular Response To Organic Cyclic Compound Regulation Of Signaling Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Intracellular Signal Transduction Positive Regulation Of Protein Kinase A Signaling Regulation Of Potassium Ion Transmembrane Transport Response To CAMP Regulation Of Membrane Potential Positive Regulation Of Transport Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity SMAD Protein Complex Assembly Response To Organophosphorus Regulation Of Delayed Rectifier Potassium Channel Activity Sexual Reproduction Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Potassium Ion Transport Epithelial Tube Morphogenesis Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transport Action Potential Tube Morphogenesis Regulation Of CAMP Biosynthetic Process Regulation Of Cellular Process Response To Organic Substance Positive Regulation Of Protein Import Into Nucleus
Tagcloud ?		atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?