AKAP6 and RYR1

Number of citations of the paper that reports this interaction (PubMedID 11590243)
0

Data Source:
BioGRID (pull down)

		AKAP6	RYR1
Description		A-kinase anchoring protein 6	ryanodine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Membrane Sarcoplasmic Reticulum T-tubule Nuclear Membrane Protein-containing Complex Calcium Channel Complex Perinuclear Region Of Cytoplasm	Cytoplasm Smooth Endoplasmic Reticulum Plasma Membrane Cell Cortex Junctional Sarcoplasmic Reticulum Membrane Terminal Cisterna Membrane Sarcoplasmic Reticulum Z Disc Organelle Membrane I Band Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma Extracellular Exosome Ryanodine Receptor Complex
	Molecular Function	Protein Binding Adenylate Cyclase Binding Protein Kinase A Regulatory Subunit Binding Protein-membrane Adaptor Activity Transmembrane Transporter Binding Protein Kinase A Binding Molecular Adaptor Activity	Nucleotide Binding Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding Calmodulin Binding ATP Binding Intracellularly Gated Calcium Channel Activity Metal Ion Binding Calcium-induced Calcium Release Activity
	Biological Process	Action Potential Protein Targeting Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Positive Regulation Of Cell Growth Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Membrane Repolarization Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport	Response To Hypoxia Outflow Tract Morphogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Muscle Contraction Striated Muscle Contraction Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Skin Development Ossification Involved In Bone Maturation Skeletal Muscle Fiber Development Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Cellular Response To Caffeine
Pathways			Stimuli-sensing channels Ion homeostasis
Drugs			Caffeine Dantrolene Suramin Tetracaine
Diseases			Central core disease
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Anorexia nervosa ( 21079607) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 29273806) Atrial fibrillation ( 29892015 30061737) Bipolar disorder ( 31043756) Body mass index ( 28448500 28892062 25673413 29273807) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Coffee consumption ( 31046077) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Creatine kinase levels ( 29403010) Diisocyanate-induced asthma ( 25918132) Economic and political preferences (environmentalism) ( 22566634) Fasting blood insulin (BMI interaction) ( 22581228) Femur bone mineral density x serum urate levels interaction ( 34046847) General cognitive ability ( 29844566) Glioma ( 28346443) HDL cholesterol levels ( 32203549) Intelligence (MTAG) ( 29326435) Night sleep phenotypes ( 27126917) Non-glioblastoma glioma ( 28346443) Photic sneeze reflex ( 27182965) PR interval ( 32439900) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Type 2 diabetes ( 30297969) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Walking pace ( 33128006)	Abstraction and mental flexibility ( 31596458) Appendicular lean mass ( 33097823) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Diisocyanate-induced asthma ( 25918132) Peanut allergy (parent-of-origin effect) ( 29489655) White blood cell count (basophil) ( 27863252)
Interacting Genes		11 interacting genes: CALM1 CDC5L DISC1 DTNBP1 NRIP1 PCNT PDE4D PPP2CA PRKAR2A RYR1 RYR2	19 interacting genes: AKAP6 ANK1 CACNA1S CALM1 CAMK2G CAV3 FKBP1A HOMER1 HOMER2 HOMER3 MTDH PDLIM3 PRKACA PRKG1 RYR2 S100A1 TRDN TTN TULP3
Entrez ID		9472	6261
HPRD ID		05257	01618
Ensembl ID		ENSG00000151320	ENSG00000196218
Uniprot IDs		B2RP22 Q13023	A0A8I5KSR1 M0R014 P21817
PDB IDs			6UHI 6UHS
Enriched GO Terms of Interacting Partners?		Calcium Channel Complex Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Caffeine Cellular Response To Purine-containing Compound Regulation Of Sequestering Of Calcium Ion Response To Caffeine Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Striated Muscle Contraction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sarcolemma Cellular Response To Alkaloid Calcium-induced Calcium Release Activity Positive Regulation Of The Force Of Heart Contraction Intracellular Signal Transduction Transmembrane Transporter Binding Response To Purine-containing Compound Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Muscle Contraction Calcium-mediated Signaling Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Signal Transduction Junctional Sarcoplasmic Reticulum Membrane Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Intracellular Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Calmodulin Binding Regulation Of Heart Contraction Cellular Response To Epinephrine Stimulus Muscle Contraction Calcium Ion Transport Into Cytosol Protein Kinase A Catalytic Subunit Binding Calcium Ion Homeostasis Detection Of Calcium Ion Regulation Of Calcium Ion Transport Response To Epinephrine Striated Muscle Contraction Sarcoplasmic Reticulum Calcium Ion Transport Response To Alkaloid Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium Ion Transmembrane Import Into Cytosol Regulation Of Muscle System Process Regulation Of Blood Circulation Muscle System Process	Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Regulation Of Metal Ion Transport Regulation Of Muscle System Process Regulation Of Monoatomic Ion Transport Z Disc Transmembrane Transporter Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of System Process Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Sequestering Of Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Transport Regulation Of Striated Muscle Contraction G Protein-coupled Glutamate Receptor Binding Regulation Of Heart Contraction Muscle System Process Regulation Of Blood Circulation Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Calcium Channel Complex Calcium-mediated Signaling Regulation Of Calcium-mediated Signaling Sarcoplasmic Reticulum Membrane Signal Transduction Regulation Of Multicellular Organismal Process Junctional Sarcoplasmic Reticulum Membrane Calcium Channel Regulator Activity Regulation Of Store-operated Calcium Entry G Protein-coupled Glutamate Receptor Signaling Pathway System Process Striated Muscle Cell Development Intracellular Signaling Cassette Striated Muscle Contraction Muscle Contraction Cardiac Muscle Hypertrophy M Band Protein Kinase A Regulatory Subunit Binding I Band Response To Muscle Stretch Negative Regulation Of Interleukin-2 Production Muscle Hypertrophy Muscle Cell Development Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Heart Rate Intracellular Signal Transduction
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