TMEM108 and ARHGEF6

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		TMEM108	ARHGEF6
Gene Name		transmembrane protein 108	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Integral Component Of Membrane	Intracellular Cytosol Cell-cell Junction Lamellipodium
	Molecular Function	Molecular_function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Biological_process	Apoptotic Process JNK Cascade Small GTPase Mediated Signal Transduction Lamellipodium Assembly Positive Regulation Of Rho GTPase Activity Cell Junction Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Cell junction organization Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G alpha (12/13) signalling events Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		IgE grass sensitization ( 22036096) Menarche (age at onset) ( 21102462)
Protein-Protein Interactions		4 interactors: ANXA7 ARHGEF6 NOTCH3 SH3GL2	22 interactors: ADAM15 ARHGEF7 BMPR1B CAPNS1 CDC42 EPHB2 GIT1 GPRASP2 PAK1 PAK2 PAK3 PARVB SH2D1A SH3GL3 SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 YWHAG ZNF580
Entrez ID		66000	9459
HPRD ID		11329	02226
Ensembl ID		ENSG00000144868	ENSG00000129675
Uniprot IDs		E9PB58 Q6UXF1	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?			Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Morphogenesis Cell Morphogenesis Involved In Differentiation Ephrin Receptor Signaling Pathway Cell Development Intracellular Signal Transduction Anatomical Structure Morphogenesis Axon Guidance Chemotaxis Signal Transduction By Phosphorylation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Differentiation Nervous System Development System Development Cell Morphogenesis Axonogenesis Primary MiRNA Processing Regulation Of Cellular Component Organization Axon Development Generation Of Neurons Positive Regulation Of Cell Differentiation Regulation Of Cell Development Regulation Of Signaling Regulation Of Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Apoptotic Process Cell Morphogenesis Involved In Neuron Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death SMAD Protein Complex Assembly Positive Regulation Of Cell Death Regulation Of Cell Adhesion Neurogenesis Locomotion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Neuron Projection Morphogenesis Multicellular Organismal Development Signaling Regulation Of Signal Transduction Cell Communication Anatomical Structure Development Response To External Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Growth Positive Regulation Of Cell Development Regulation Of Cell Proliferation Heart Development Embryonic Cranial Skeleton Morphogenesis Signal Transduction
Tagcloud ?			acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Difference) ?			acted analyzing bioinformatic constructed crc dataset david degs disturbed downloaded fzd2 gse23878 hprd hub intend jup kegg module modules networks omnibus pdgfrb prkcb student theses uncovered wnt11 wnt2 wnt5a
Tagcloud (Intersection) ?