CXCL9 and LRRC25

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCL9	LRRC25
Description		C-X-C motif chemokine ligand 9	leucine rich repeat containing 25
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytoplasm Endoplasmic Reticulum Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Protein Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Bacterium Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Body size at age 10 ( 32376654) Hyperemesis gravidarum ( 29563502) Monocyte percentage of white cells ( 27863252 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) Systemic lupus erythematosus ( 28714469 33536424) White blood cell count ( 32888494)
Interacting Genes		76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1	38 interacting genes: ACD AGPAT4 ANKRD46 APOL3 ATP6V0C BMP10 BRICD5 C3orf52 CD72 CLDN19 CLEC1A CLN6 CLRN2 CNIH3 CXCL9 DEFB121 DNAJC30 EDDM3B FAM3C FATE1 FPR2 GPRC5D LHFPL5 MAL OPRM1 PKMYT1 PNLIPRP1 SEC22A SEC61G SMCO4 SPNS3 TMEM120A TMEM201 TNF TRAF3IP3 TSPAN4 VAMP5 YIPF6
Entrez ID		4283	126364
HPRD ID		03416	09597
Ensembl ID		ENSG00000138755	ENSG00000175489
Uniprot IDs		Q07325	Q8N386
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Migration Cytokine Activity Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Mononuclear Cell Migration Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Killing Of Cells Of Another Organism Immune Response Immune System Process Humoral Immune Response Myeloid Leukocyte Migration Defense Response Cell Killing Lymphocyte Migration T Cell Migration Lymphocyte Chemotaxis CCR Chemokine Receptor Binding Cell Migration T Cell Chemotaxis Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Migration Eosinophil Migration Chemokine Receptor Binding Defense Response To Symbiont Cell Motility Defense Response To Other Organism Positive Regulation Of Chemotaxis Regulation Of Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Regulation Of Chemotaxis Regulation Of T Cell Chemotaxis Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Protein Binding Positive Regulation Of T Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of Immune System Process G Protein-coupled Receptor Signaling Pathway	Membrane Detection Of Mechanical Stimulus Involved In Sensory Perception
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