CXCL9 and GPR42

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCL9	GPR42
Description		C-X-C motif chemokine ligand 9	G protein-coupled receptor 42
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Plasma Membrane Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Bacterium Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion	Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1	110 interacting genes: ADGRE2 ADIPOQ ALOX5AP ANKRD46 APOD ATP13A1 ATP4B ATP6V0B ATP6V0C BNIP3 BTN2A2 C1GALT1 CATSPERH CCDC167 CCL4L2 CD300C CD79A CLCA4 CLEC2D CMTM5 COMT CTXN3 CXCL16 CXCL9 DRAM1 EFNA5 EMP1 ERG28 ERMP1 FAM3C FXYD3 FXYD6 GIMAP5 GJB2 GOSR2 GPR37L1 GYPC IER3IP1 IGFBP5 IL1RL1 ITGAM JPH1 KCNA1 KLRG1 LAT LEPROTL1 LHFPL5 LNPEP LTC4S MFSD6 MGAM MS4A1 MS4A13 NDUFB11 NINJ2 NRM NSG1 PAEP PLP1 PLPP1 PMP22 PNLIPRP1 RPRM RTP2 RUSF1 SCD SERINC1 SERP2 SERTM1 SLC30A2 SLC30A3 SLC30A8 SLC35E4 SLC38A1 SLC38A7 SLC39A2 SLC41A1 SLC41A2 SLC61A1 SMCO4 SMIM3 STATH STRIT1 STX8 SYNDIG1 SYNGR1 TEX264 TF TM4SF4 TMBIM6 TMEM128 TMEM140 TMEM147 TMEM182 TMEM19 TMEM237 TMEM239 TMEM242 TMEM30B TMEM60 TMEM65 TRARG1 TREX1 TSPO2 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZFPL1
Entrez ID		4283	2866
HPRD ID		03416	16033
Ensembl ID		ENSG00000138755	ENSG00000126251
Uniprot IDs		Q07325	A0A0K0PUY3 O15529
PDB IDs
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Migration Cytokine Activity Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Mononuclear Cell Migration Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Killing Of Cells Of Another Organism Immune Response Immune System Process Humoral Immune Response Myeloid Leukocyte Migration Defense Response Cell Killing Lymphocyte Migration T Cell Migration Lymphocyte Chemotaxis CCR Chemokine Receptor Binding Cell Migration T Cell Chemotaxis Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Migration Eosinophil Migration Chemokine Receptor Binding Defense Response To Symbiont Cell Motility Defense Response To Other Organism Positive Regulation Of Chemotaxis Regulation Of Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Regulation Of Chemotaxis Regulation Of T Cell Chemotaxis Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Protein Binding Positive Regulation Of T Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of Immune System Process G Protein-coupled Receptor Signaling Pathway	Membrane Plasma Membrane Monoatomic Ion Transport Monoatomic Cation Transmembrane Transporter Activity Protein Binding Metal Ion Transport Monoatomic Cation Transport Endoplasmic Reticulum Inorganic Ion Transmembrane Transport Transmembrane Transport Endoplasmic Reticulum Membrane Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Golgi Trans Cisterna Zinc Ion Transmembrane Transport Golgi Medial Cisterna Zinc Ion Transport Zinc Ion Import Into Organelle Monoatomic Cation Homeostasis Zinc Ion Import Into Lysosome Intracellular Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Leukotriene-C4 Synthase Activity Chemical Homeostasis Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Zinc:proton Antiporter Activity Cellular Response To Magnesium Ion
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