CXCL9 and PTPN5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CXCL9	PTPN5
Gene Name		chemokine (C-X-C motif) ligand 9	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CXCR3 Chemokine Receptor Binding	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity
	Biological Process	Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling T Cell Chemotaxis Positive Regulation Of CAMP Metabolic Process Response To Lipopolysaccharide Regulation Of Cell Proliferation Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Chemokine-mediated Signaling Pathway Positive Regulation Of Myoblast Fusion	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065)
Protein-Protein Interactions		9 interactors: BMF CCDC155 CCR3 CXCR3 DPP4 PAX8 PTPN5 SFTPC SYNE4	11 interactors: CUL5 CXCL9 FAM58A FYN MAPK1 MAPK3 SNX4 TERF1 TMEM51 VTI1B ZBTB5
Entrez ID		4283	84867
HPRD ID		03416	01472
Ensembl ID		ENSG00000138755	ENSG00000110786
Uniprot IDs		Q07325	B7Z2F8 B7ZAF5 P54829 Q86TL3
PDB IDs			2BIJ 2BV5 2CJZ
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chromosome Localization To Nuclear Envelope Involved In Synapsis Regulation Of Thyroid-stimulating Hormone Secretion Regulation Of Endothelial Cell Proliferation Pronephric Field Specification Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Chemokine (C-C Motif) Ligand 11 Production Positive Regulation Of Angiogenesis Positive Regulation Of Thyroid Hormone Generation Kidney Rudiment Formation Thyroid-stimulating Hormone Signaling Pathway Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cytosolic Calcium Ion Concentration Metanephric Comma-shaped Body Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Response To Cytokine Cytosolic Calcium Ion Homeostasis Metanephric Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Metanephric S-shaped Body Morphogenesis Regulation Of Thyroid Hormone Generation Comma-shaped Body Morphogenesis Anoikis Establishment Of Apical/basal Cell Polarity Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Polarized Epithelial Cell Differentiation Positive Regulation Of Cell Proliferation Regulation Of Angiogenesis Pronephros Development Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Homooligomerization S-shaped Body Morphogenesis Positive Regulation Of Intracellular Transport T Cell Chemotaxis Metanephric Distal Tubule Development Regulation Of Cell-cell Adhesion Mediated By Integrin Chemokine Production Establishment Of Monopolar Cell Polarity Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation	Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Regulation Of Cellular Localization Regulation Of Golgi Organization Sensory Perception Of Pain Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Transport Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Response To Epidermal Growth Factor Viral Process Platelet Activation Response To Fibroblast Growth Factor Regulation Of Cellular Response To Heat Regulation Of Cellular Component Organization Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process Phagocytosis Response To Exogenous DsRNA Fc Receptor Signaling Pathway Cell Proliferation Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Vesicle-mediated Transport Toll-like Receptor 10 Signaling Pathway Cellular Response To Peptide Hormone Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Response To Lipopolysaccharide Toll-like Receptor 2 Signaling Pathway
Tagcloud ?		academic assessing auc bacilli centre chemoattractant cxcl10 cxcl11 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide
Tagcloud (Difference) ?		academic assessing auc bacilli centre chemoattractant cxcl10 cxcl11 cxcr3 diagnosing differentiating gamma grades ifn immunoassays inducible ligands mig monokine pulmonary radiographic smear sputum surrogate tac tb tertiary usefulness	ad aggregated aggregates amyloid beneficial biology burden called discovery disrupts economic enriched hyperphosphorylated making millions modulating neurofibrillary neuropathology nfts plaques representing reviews step striatal substantial tangles trafficking turn worldwide
Tagcloud (Intersection) ?