CXCL9 and CLEC4E

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CXCL9	CLEC4E
Description		C-X-C motif chemokine ligand 9	C-type lectin domain family 4 member E
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Phagocytic Cup Plasma Membrane External Side Of Plasma Membrane Membrane Phagocytic Vesicle Membrane Cell Projection
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Calcium Ion Binding Protein Binding Carbohydrate Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Metal Ion Binding Glycolipid Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Bacterium Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion	Positive Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway T Cell Differentiation Involved In Immune Response Immune System Process Immune Response-regulating Signaling Pathway Immune Response Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Innate Immune Response Antifungal Innate Immune Response
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Dectin-2 family Dectin-2 family
Drugs			Cholesterol
Diseases
GWAS		Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Takayasu arteritis ( 25604533)
Interacting Genes		76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1	4 interacting genes: CXCL9 FAM3C FCER1G NKG7
Entrez ID		4283	26253
HPRD ID		03416	13075
Ensembl ID		ENSG00000138755	ENSG00000166523
Uniprot IDs		Q07325	F5H5X7 Q9ULY5
PDB IDs			3WH2 3WH3
Enriched GO Terms of Interacting Partners?		Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Migration Cytokine Activity Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Mononuclear Cell Migration Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Killing Of Cells Of Another Organism Immune Response Immune System Process Humoral Immune Response Myeloid Leukocyte Migration Defense Response Cell Killing Lymphocyte Migration T Cell Migration Lymphocyte Chemotaxis CCR Chemokine Receptor Binding Cell Migration T Cell Chemotaxis Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Migration Eosinophil Migration Chemokine Receptor Binding Defense Response To Symbiont Cell Motility Defense Response To Other Organism Positive Regulation Of Chemotaxis Regulation Of Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Regulation Of Chemotaxis Regulation Of T Cell Chemotaxis Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Protein Binding Positive Regulation Of T Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of Immune System Process G Protein-coupled Receptor Signaling Pathway	Granulocyte Migration Defense Response Neutrophil Chemotaxis Myeloid Leukocyte Migration IgE Receptor Activity Regulated Exocytosis Defense Response To Other Organism Leukocyte Degranulation Granulocyte Chemotaxis Neutrophil Migration Lymphocyte Mediated Immunity Defense Response To Symbiont Inflammatory Response Killing Of Cells Of Another Organism Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Leukocyte Chemotaxis Positive Regulation Of Type I Hypersensitivity Leukocyte Mediated Immunity Myeloid Leukocyte Differentiation Fc-epsilon Receptor I Complex Negative Regulation Of Mast Cell Apoptotic Process Serotonin Secretion By Platelet Fc-gamma Receptor III Complex Positive Regulation Of Inflammatory Response Positive Regulation Of Type III Hypersensitivity Cell Killing Cell Chemotaxis Mast Cell Apoptotic Process Serotonin Secretion Positive Regulation Of Type IIa Hypersensitivity Exocytosis Cytokine Activity Cytolytic Granule Membrane Response To Other Organism Leukocyte Migration Response To Stress Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process CXCR3 Chemokine Receptor Binding Immune Response Myeloid Cell Differentiation Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Natural Killer Cell Degranulation Immune Response To Tumor Cell Response To External Biotic Stimulus Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Mast Cell Activation T Cell Activation
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