TNFSF8 and CXCL9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNFSF8	CXCL9
Description		TNF superfamily member 8	C-X-C motif chemokine ligand 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Extracellular Region Extracellular Space External Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium	Chemotaxis Defense Response Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Bacterium Neutrophil Chemotaxis Killing Of Cells Of Another Organism Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion
Pathways		TNFs bind their physiological receptors	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 23266558 30500874 21102463) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)	Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		4 interacting genes: ANG BMP10 CXCL9 TNFRSF8	76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1
Entrez ID		944	4283
HPRD ID		04852	03416
Ensembl ID		ENSG00000106952	ENSG00000138755
Uniprot IDs		A0A087X228 P32971 Q52M88	Q07325
PDB IDs
Enriched GO Terms of Interacting Partners?		Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide TRNA Stabilization Antimicrobial Humoral Response Humoral Immune Response TRNA-specific Ribonuclease Activity Regulation Of Cell Population Proliferation Angiogenin-PRI Complex Positive Regulation Of TRAIL Production Regulation Of TRAIL Production CXCR3 Chemokine Receptor Binding Cytokine Activity Positive Regulation Of Sarcomere Organization Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Regulation Of Sarcomere Organization Negative Regulation Of Translation In Response To Stress Extracellular Space Ventricular Cardiac Muscle Cell Development TRNA Decay Antifungal Humoral Response CXCR Chemokine Receptor Binding Adult Heart Development Response To Bacterium Heart Trabecula Formation Response To Yeast Signal Transduction Positive Regulation Of Myoblast Fusion	Chemokine Activity Cell Chemotaxis Leukocyte Chemotaxis Chemotaxis Locomotion Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Leukocyte Migration Cytokine Activity Antimicrobial Humoral Response Chemokine-mediated Signaling Pathway Mononuclear Cell Migration Granulocyte Chemotaxis Inflammatory Response Granulocyte Migration Killing Of Cells Of Another Organism Immune Response Immune System Process Humoral Immune Response Myeloid Leukocyte Migration Defense Response Cell Killing Lymphocyte Migration T Cell Migration Lymphocyte Chemotaxis CCR Chemokine Receptor Binding Cell Migration T Cell Chemotaxis Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Regulation Of Leukocyte Migration Eosinophil Migration Chemokine Receptor Binding Defense Response To Symbiont Cell Motility Defense Response To Other Organism Positive Regulation Of Chemotaxis Regulation Of Lymphocyte Chemotaxis CXCR Chemokine Receptor Binding Regulation Of Chemotaxis Regulation Of T Cell Chemotaxis Response To Other Organism Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Protein Binding Positive Regulation Of T Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Lymphocyte Migration Positive Regulation Of Lymphocyte Migration Regulation Of Immune System Process G Protein-coupled Receptor Signaling Pathway
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