TNFSF8 and TNFRSF8

Number of citations: 0 (PubMedID 11754357)
Data Source: HPRD (in vitro)

		TNFSF8	TNFRSF8
Name		TNF superfamily member 8	TNF receptor superfamily member 8
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Nucleoplasm Cytoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protease Binding Transmembrane Signaling Receptor Activity
	Biological Process	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs		None	Iratumumab XmAb 2513 Brentuximab vedotin
GWAS		Arthritis (juvenile idiopathic) ( 33106285 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Composite immunoglobulin trait (IgA/IgG) ( 28628107 ) Crohn's disease ( 23266558 30500874 21102463 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) IgA levels ( 28628107 ) Inflammatory bowel disease ( 27569725 23128233 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Primary biliary cholangitis ( 28425483 30643196 ) Sum eosinophil basophil counts ( 27863252 ) Ulcerative colitis ( 21297633 )	Asthma ( 31959851 32296059 34103634 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Neutrophil percentage of granulocytes ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Sum eosinophil basophil counts ( 27863252 ) Tuberculosis ( 29036319 )
Novel Interactors		None recorded	7 novel interactors: CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 WRAP73
Interacting Genes		4 interacting genes: ANG BMP10 CXCL9 TNFRSF8	7 interacting genes: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		944	943
HPRD ID		04852	01074
Ensembl ID		ENSG00000106952	ENSG00000120949
Uniprot IDs		A0A087X228 P32971 Q52M88	A5D8T4 P28908
PDB IDs		Not available	1D01
GO Terms Enriched among Interactors		Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide TRNA Stabilization Antimicrobial Humoral Response Humoral Immune Response TRNA-specific Ribonuclease Activity Regulation Of Cell Population Proliferation Angiogenin-PRI Complex Positive Regulation Of TRAIL Production Regulation Of TRAIL Production CXCR3 Chemokine Receptor Binding Cytokine Activity Positive Regulation Of Sarcomere Organization Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Regulation Of Sarcomere Organization Negative Regulation Of Translation In Response To Stress Extracellular Space Ventricular Cardiac Muscle Cell Development TRNA Decay Antifungal Humoral Response CXCR Chemokine Receptor Binding Adult Heart Development Response To Bacterium Heart Trabecula Formation Response To Yeast Signal Transduction Positive Regulation Of Myoblast Fusion	Tumor Necrosis Factor Receptor Binding Thioesterase Binding CD40 Receptor Complex Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Positive Regulation Of DNA-binding Transcription Factor Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Ubiquitin Protein Ligase Binding Cytoplasmic Side Of Plasma Membrane Regulation Of Canonical NF-kappaB Signal Transduction Identical Protein Binding Cytokine-mediated Signaling Pathway Signal Transduction Neuron Development Signal Transduction Involved In Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Receptor Complex Apoptotic Process Response To Environmental Enrichment Transmembrane Receptor Protein Tyrosine Kinase Activity Cell Death Notochord Cell Development Programmed Cell Death TORC2 Complex Disassembly MWP Complex 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Stabilization Swimming Behavior Axial Mesoderm Formation Response To Ketamine TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of RNA Metabolic Process Receptor Signaling Protein Tyrosine Kinase Activator Activity Core-binding Factor Complex Negative Regulation Of Lymphangiogenesis Notochord Formation I-kappaB Phosphorylation Negative Regulation Of Male Germ Cell Proliferation Protein Phosphorylation