TNFSF8 and TNFRSF8

Number of citations of the paper that reports this interaction (PMID 11754357)
8

Data Source:
HPRD (in vitro)

		TNFSF8	TNFRSF8
Gene Name		tumor necrosis factor (ligand) superfamily, member 8	tumor necrosis factor receptor superfamily, member 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium	Signal Transduction Negative Regulation Of Cell Proliferation Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of TRAIL Biosynthetic Process Cellular Response To Mechanical Stimulus
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 23266558) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: ANG TNFRSF8	7 interactors: ALK TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5
Entrez ID		944	943
HPRD ID		04852	01074
Ensembl ID			ENSG00000120949
Uniprot IDs		P32971 Q52M88	A5D8T4 B9EGD9 D3YTD8 P28908
PDB IDs			1D01
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TRAIL Biosynthetic Process Diacylglycerol Biosynthetic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Negative Regulation Of Cell Proliferation Regulation Of Phospholipase A2 Activity Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Diacylglycerol Metabolic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process RRNA Transcription Oocyte Maturation Response To Abiotic Stimulus Activation Of Protein Kinase B Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Actin Filament Polymerization Oocyte Development Oocyte Differentiation Regulation Of Cell Proliferation Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Ovarian Follicle Development Cellular Response To Mechanical Stimulus Positive Regulation Of Phospholipase Activity Oogenesis Regulation Of Endothelial Cell Proliferation Regulation Of Phospholipase Activity Negative Regulation Of Translation Actin Polymerization Or Depolymerization Positive Regulation Of Lipase Activity Regulation Of Tumor Necrosis Factor Production Ovulation Cycle Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Protein Metabolic Process Neutral Lipid Metabolic Process Protein Polymerization RNA Phosphodiester Bond Hydrolysis Regulation Of Cytokine Biosynthetic Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Cellular Metabolic Process Cell Maturation Positive Regulation Of Epithelial Cell Proliferation	Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Death Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Signaling NIK/NF-kappaB Signaling Cell Communication Cellular Response To Stimulus TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Toll-like Receptor 4 Signaling Pathway Regulation Of Metabolic Process Cellular Response To Tumor Necrosis Factor Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Protein Ubiquitination Response To Tumor Necrosis Factor Protein Modification By Small Protein Conjugation Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Innate Immune Response Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of MAP Kinase Activity Toll Signaling Pathway Cellular Response To Nitric Oxide CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Immunoglobulin Secretion Response To Nitric Oxide
Tagcloud ?		abc bcl2af1 bcl2l10 biology casp10 casp14 casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tunel valuable	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine traf2 unexpected
Tagcloud (Difference) ?		abc bcl2af1 bcl2l10 biology casp10 casp14 casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tunel valuable	abrogates alanine artificially ascorbate canonical cd30 cd30v checkpoint concurrently endogenously h2o2 hesc hescs makes nfkappab overexpress purification resides residue restores subcellular substitution surprisingly t61 t61a thr61 threonine traf2 unexpected
Tagcloud (Intersection) ?