TNFSF8 and ANG

Number of citations of the paper that reports this interaction (PMID 11751393)
6

Data Source:
HPRD (in vitro)

		TNFSF8	ANG
Gene Name		tumor necrosis factor (ligand) superfamily, member 8	angiogenin, ribonuclease, RNase A family, 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane	Basal Lamina Extracellular Space Nucleus Nucleolus Growth Cone Angiogenin-PRI Complex Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	DNA Binding Actin Binding Endonuclease Activity Ribonuclease Activity Receptor Binding Copper Ion Binding Protein Binding Heparin Binding RRNA Binding Peptide Binding
	Biological Process	Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Defense Response To Gram-positive Bacterium	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Placenta Development Positive Regulation Of Endothelial Cell Proliferation Diacylglycerol Biosynthetic Process Cell Communication Activation Of Phospholipase C Activity RRNA Transcription Response To Hormone Cell Migration Negative Regulation Of Translation Actin Filament Polymerization Activation Of Protein Kinase B Activity Activation Of Phospholipase A2 Activity Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Nucleic Acid Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis
Pathways
Drugs			Pyrophosphate 2- Pyroglutamic Acid Citric Acid
Diseases
GWAS		Crohn's disease ( 21102463 23266558) Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		2 interactors: ANG TNFRSF8	8 interactors: ABCG8 ACTC1 ACTN2 ATP6AP1 PTEN RNH1 TDGF1 TNFSF8
Entrez ID		944	283
HPRD ID		04852	00105
Ensembl ID			ENSG00000214274
Uniprot IDs		P32971 Q52M88	P03950
PDB IDs			1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of TRAIL Biosynthetic Process Diacylglycerol Biosynthetic Process Activation Of Phospholipase A2 Activity Positive Regulation Of Phospholipase A2 Activity Negative Regulation Of Cell Proliferation Regulation Of Phospholipase A2 Activity Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Diacylglycerol Metabolic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process RRNA Transcription Oocyte Maturation Response To Abiotic Stimulus Activation Of Protein Kinase B Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Smooth Muscle Cell Proliferation Actin Filament Polymerization Oocyte Development Oocyte Differentiation Regulation Of Cell Proliferation Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Ovarian Follicle Development Cellular Response To Mechanical Stimulus Positive Regulation Of Phospholipase Activity Oogenesis Regulation Of Endothelial Cell Proliferation Regulation Of Phospholipase Activity Negative Regulation Of Translation Actin Polymerization Or Depolymerization Positive Regulation Of Lipase Activity Regulation Of Tumor Necrosis Factor Production Ovulation Cycle Process Regulation Of Smooth Muscle Cell Proliferation Regulation Of Protein Metabolic Process Neutral Lipid Metabolic Process Protein Polymerization RNA Phosphodiester Bond Hydrolysis Regulation Of Cytokine Biosynthetic Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Cellular Metabolic Process Cell Maturation Positive Regulation Of Epithelial Cell Proliferation	Cardiac Muscle Tissue Development Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Striated Muscle Tissue Development Muscle Tissue Development Actin Filament-based Movement Negative Regulation Of Transport Endothelial Cell Migration Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Epithelial Cell Migration Epithelium Migration Response To Drug Heart Development Cardiac Muscle Cell Differentiation Negative Regulation Of Intestinal Phytosterol Absorption Negative Regulation Of Intestinal Cholesterol Absorption Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Regulation Of Cell-matrix Adhesion Regulation Of Apoptotic Process Movement Of Cell Or Subcellular Component Cardiocyte Differentiation Response To Ethanol Negative Regulation Of Dendritic Spine Morphogenesis Regulation Of Cell Death Negative Regulation Of Ribosome Biogenesis Central Nervous System Myelin Maintenance Positive Regulation Of Osteoclast Development Ameboidal-type Cell Migration Regulation Of Presynaptic Membrane Organization Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell-substrate Adhesion Negative Regulation Of Dendritic Spine Development Microspike Assembly Rhythmic Synaptic Transmission Skeletal Muscle Thin Filament Assembly Activation Of Anaphase-promoting Complex Activity Synapse Maturation Muscle Contraction Response To Nutrient Cardiovascular System Development Striated Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Intestinal Cholesterol Absorption Male Mating Behavior
Tagcloud ?		abc bcl2af1 bcl2l10 biology casp10 casp14 casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 needle neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tunel valuable	ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms needle probes renin salt upregulates vasodilatory
Tagcloud (Difference) ?		abc bcl2af1 bcl2l10 biology casp10 casp14 casp8 cd70 changed cideb cluster correlate fadd hierarchical hrk igf1r mcl1 neoadjuvant pathologic profiling prognosis reflect removed substantially therapeutically tunel valuable	ace angiotensin b2 bk blockade blocker cbf circulation contributions converting dogs doppler enalaprilat icatibant intake intrarenal kallikrein kinin maintained mbf medullary micergrams micrograms probes renin salt upregulates vasodilatory
Tagcloud (Intersection) ?		needle