TNFSF8 and ANG

Number of citations of the paper that reports this interaction (PubMedID 11751393)
0

Data Source:
HPRD (in vitro)

		TNFSF8	ANG
Description		TNF superfamily member 8	angiogenin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane	Extracellular Region Basement Membrane Extracellular Space Nucleus Chromosome Nucleolus Cytoplasm Cytosol Cytoplasmic Stress Granule Actin Cytoskeleton Endocytic Vesicle Growth Cone Angiogenin-PRI Complex Neuronal Cell Body
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Nucleic Acid Binding DNA Binding Actin Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Nuclease Activity TRNA-specific Ribonuclease Activity Signaling Receptor Binding Copper Ion Binding Protein Binding Heparin Binding Hydrolase Activity RRNA Binding Peptide Binding Protein Homodimerization Activity Ribosome Binding Receptor Ligand Activity
	Biological Process	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium	Angiogenesis Ovarian Follicle Development Oocyte Maturation Response To Hypoxia Response To Yeast Placenta Development Positive Regulation Of Endothelial Cell Proliferation Cytoplasmic Translation Receptor-mediated Endocytosis Cell Communication Signal Transduction RRNA Transcription Response To Hormone TRNA Decay Cell Migration Negative Regulation Of Translation Antibacterial Humoral Response Antifungal Humoral Response Signaling Actin Filament Polymerization Cell Differentiation Negative Regulation Of Translation In Response To Stress Cellular Response To Stress Stress Granule Assembly TRNA Stabilization Positive Regulation Of Phosphorylation Homeostatic Process Negative Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Hematopoietic Stem Cell Proliferation
Pathways		TNFs bind their physiological receptors	Adherens junctions interactions tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 23266558 30500874 21102463) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)	Blood protein levels ( 30072576)
Interacting Genes		4 interacting genes: ANG BMP10 CXCL9 TNFRSF8	8 interacting genes: ABCG8 ACTC1 ACTN2 ATP6AP1 CRIPTO PTEN RNH1 TNFSF8
Entrez ID		944	283
HPRD ID		04852	00105
Ensembl ID		ENSG00000106952	ENSG00000214274
Uniprot IDs		A0A087X228 P32971 Q52M88	P03950 W0UV28
PDB IDs			1A4Y 1ANG 1AWZ 1B1E 1B1I 1B1J 1GV7 1H0D 1H52 1H53 1HBY 1K58 1K59 1K5A 1K5B 1UN3 1UN4 1UN5 2ANG 4AHD 4AHE 4AHF 4AHG 4AHH 4AHI 4AHJ 4AHK 4AHL 4AHM 4AHN 4AOH 4B36 5EOP 5EPZ 5EQO 5M9A 5M9C 5M9G 5M9J 5M9M 5M9P 5M9Q 5M9R 5M9S 5M9T 5M9V 7NPM 7PNJ 7PNP 7PNR 8AF0 9BDL 9BDN 9BDP
Enriched GO Terms of Interacting Partners?		Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide TRNA Stabilization Antimicrobial Humoral Response Humoral Immune Response TRNA-specific Ribonuclease Activity Regulation Of Cell Population Proliferation Angiogenin-PRI Complex Positive Regulation Of TRAIL Production Regulation Of TRAIL Production CXCR3 Chemokine Receptor Binding Cytokine Activity Positive Regulation Of Sarcomere Organization Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Regulation Of Sarcomere Organization Negative Regulation Of Translation In Response To Stress Extracellular Space Ventricular Cardiac Muscle Cell Development TRNA Decay Antifungal Humoral Response CXCR Chemokine Receptor Binding Adult Heart Development Response To Bacterium Heart Trabecula Formation Response To Yeast Signal Transduction Positive Regulation Of Myoblast Fusion	Filopodium Sarcomere Synapse Actin Filament Titin Z Domain Binding Actin Filament Uncapping Plasma Membrane Apical Plasma Membrane Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Angiogenin-PRI Complex Negative Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Intestinal Phytosterol Absorption Actomyosin Structure Organization Phospholipase C-activating Angiotensin-activated Signaling Pathway Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Ribonuclease Inhibitor Activity Nodal Binding Negative Regulation Of Intestinal Absorption
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