TNFSF8

Description		TNF superfamily member 8
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Immune Response Cell Communication Signal Transduction Cell-cell Signaling Signaling Regulation Of T Cell Proliferation CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-positive Bacterium
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Composite immunoglobulin trait (IgA/IgG) ( 28628107) Crohn's disease ( 23266558 30500874 21102463) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgA levels ( 28628107) Inflammatory bowel disease ( 27569725 23128233) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 30643196) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 21297633)
Interacting Genes		4 interacting genes: ANG BMP10 CXCL9 TNFRSF8
Entrez ID		944
HPRD ID		04852
Ensembl ID		ENSG00000106952
Uniprot IDs		A0A087X228 P32971 Q52M88
PDB IDs
Enriched GO Terms of Interacting Partners?		Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide TRNA Stabilization Antimicrobial Humoral Response Humoral Immune Response TRNA-specific Ribonuclease Activity Regulation Of Cell Population Proliferation Angiogenin-PRI Complex Positive Regulation Of TRAIL Production Regulation Of TRAIL Production CXCR3 Chemokine Receptor Binding Cytokine Activity Positive Regulation Of Sarcomere Organization Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Receptor Serine/threonine Kinase Binding Atrial Cardiac Muscle Tissue Morphogenesis Telethonin Binding Regulation Of Sarcomere Organization Negative Regulation Of Translation In Response To Stress Extracellular Space Ventricular Cardiac Muscle Cell Development TRNA Decay Antifungal Humoral Response CXCR Chemokine Receptor Binding Adult Heart Development Response To Bacterium Heart Trabecula Formation Response To Yeast Signal Transduction Positive Regulation Of Myoblast Fusion
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