ZBTB7B and GRAP2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZBTB7B	GRAP2
Gene Name		zinc finger and BTB domain containing 7B	GRB2-related adaptor protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol
	Molecular Function	DNA Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Ectoderm Development Cell Differentiation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response T Cell Receptor Signaling Pathway
Pathways			DAP12 interactions Generation of second messenger molecules Costimulation by the CD28 family CD28 co-stimulation FCERI mediated MAPK activation Signaling by SCF-KIT DAP12 signaling TCR signaling Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)
Protein-Protein Interactions		17 interactors: BCL6 EP300 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN PIN1 RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 ZBTB5 ZNF277	31 interactors: BEND5 BLNK CCNDBP1 CD28 CSF1R ERBB2 FASLG GAB1 GAB2 GAB3 GFAP GNB2L1 HNRNPK KHDRBS1 KIT KRTAP4-12 LAT LAX1 LCP2 MAP4K1 PRPH2 RBPMS SHB SHC1 SOS2 SPRY2 STAMBP UBC USP8 YWHAE ZBTB7B
Entrez ID		51043	9402
HPRD ID		09625	05156
Ensembl ID		ENSG00000160685	ENSG00000100351
Uniprot IDs		O15156	B7Z8E3 B7Z8F8 F5H548 O75791 Q6FI14
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Regulation Of Signaling Regulation Of Cell-cell Adhesion Regulation Of Cellular Senescence Regulation Of Lymphocyte Activation Positive Regulation Of Organelle Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Component Organization ERBB Signaling Pathway Regulation Of Cell Activation Regulation Of Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Cytoskeleton Organization Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ras Protein Signal Transduction Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Viral Process Negative Regulation Of ERBB Signaling Pathway Regulation Of Protein Deacetylation Positive Regulation Of Cell-cell Adhesion Cell Surface Receptor Signaling Pathway RNA Biosynthetic Process Histone H2B Acetylation RNA Metabolic Process Regulation Of Cell Adhesion Regulation Of DNA Recombination Negative Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Component Biogenesis T Cell Costimulation Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Stimulus Immune Response Regulation Of Immune System Process Establishment Of Protein Localization To Organelle Nucleobase-containing Compound Metabolic Process Defense Response Regulation Of Actin Cytoskeleton Organization Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of Mast Cell Cytokine Production N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Isotype Switching To IgE Isotypes Cell Migration	Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Neurotrophin Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Response To Growth Factor Regulation Of MAP Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Intracellular Signal Transduction Signaling Cell Communication Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Phosphatidylinositol-mediated Signaling Regulation Of Kinase Activity Cellular Response To Growth Factor Stimulus Innate Immune Response Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Regulation Of Immune Response Immune System Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Response To Stimulus Regulation Of Phosphorylation
Tagcloud ?			a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined
Tagcloud (Difference) ?			a549 anticancer colony conditionally conversely downregulated downregulates ectopic gcip h1299 id1 interacting interacts interfering invasion invasive inversely minimally nsclc nscls oncogenic potently putative recognized suppress suppresses suppressor tumorigenicity undefined
Tagcloud (Intersection) ?