ZBTB7B and CRBN

Number of citations of the paper that reports this interaction (PubMedID 30385546)
43

Data Source:
BioGRID (pull down)

		ZBTB7B	CRBN
Description		zinc finger and BTB domain containing 7B	cereblon
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transmembrane Transporter Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway	Protein Ubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Monoatomic Ion Transmembrane Transport Locomotory Exploration Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Limb Development
Pathways			Potential therapeutics for SARS
Drugs			Lenalidomide Thalidomide Pomalidomide
Diseases			Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Immune response to smallpox vaccine (IL-6) ( 22542470) Knee osteoarthritis ( 27696742) Malaria ( 31844061) Restless legs syndrome ( 29029846) White blood cell count (basophil) ( 27863252 29403010) White matter integrity ( 23218918)
Interacting Genes		27 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B	47 interacting genes: APP APPL2 BCL6 BCL6B BSG CSNK1A1 CYP19A1 DNAJA1 EGR1 EGR4 ELF5 GLUL GRB2 GSPT1 GZF1 HDAC6 HIC1 HIC2 HMGB2 HNRNPK HSPA2 IKZF3 KDM1A KPNB1 MISP OSR1 OSR2 PAK5 PIK3R3 PRKAG1 RBPMS SALL1 SALL3 SLC16A1 SQSTM1 SUV39H1 TP53 UBE2D1 UBE2D3 UBE2G1 WIZ YWHAZ ZBTB16 ZBTB7A ZBTB7B ZFP91 ZMYM2
Entrez ID		51043	51185
HPRD ID		09625	16750
Ensembl ID		ENSG00000160685	ENSG00000113851
Uniprot IDs		O15156	Q96SW2
PDB IDs			4M91 4TZ4 5FQD 5HXB 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6H0F 6H0G 6UML 6XK9 7BQU 7BQV 7LPS 7U8F 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G66 8OIZ 8OJH 8RQ1 8RQ8 8RQ9 8RQA 8RQC 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 9CUO 9DJT 9DJX 9DQD 9FJX 9GAO
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of RNA Metabolic Process Phosphotyrosine Residue Binding Negative Regulation Of RNA Biosynthetic Process Type 2 Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Activation SH3 Domain Binding Small GTPase-mediated Signal Transduction DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleoplasm DNA Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lymphocyte Activation Positive Regulation Of Cell Adhesion Regulation Of DNA Recombination Regulation Of Cell-cell Adhesion Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Vesicle Membrane Non-canonical NF-kappaB Signal Transduction Cis-trans Isomerase Activity	Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of Metabolic Process Zinc Ion Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Metal Ion Binding Nucleoplasm RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Cellular Response To Nutrient Levels Regulation Of Signaling Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of RNA Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Sequence-specific Double-stranded DNA Binding Sequence-specific DNA Binding T Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Lymphocyte Differentiation Mesonephros Development Response To Nutrient Levels
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