ZBTB7B and SYTL4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZBTB7B	SYTL4
Description		zinc finger and BTB domain containing 7B	synaptotagmin like 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Endosome Plasma Membrane Membrane Secretory Granule Transport Vesicle Membrane Platelet Alpha Granule Membrane Cytoplasmic Vesicle Exocytic Vesicle
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Phospholipid Binding Zinc Ion Binding Small GTPase Binding Neurexin Family Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway	Plasma Membrane Repair Intracellular Protein Transport Exocytosis Insulin Secretion Lysosome Localization Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway Regulation Of Plasma Membrane Repair
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)	Lean body mass ( 28552196) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		27 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B	29 interacting genes: CCDC85B CEP70 DVL3 FCHO1 FXR2 HMG20A INS KIFC3 LMO1 LZTS1 OSBPL3 PRKAR1B RAB27A RAB27B RAB3A RAB3D RAB8A ROPN1 SNCA SPANXN2 STX1A STXBP1 TBC1D1 TRIM37 TRIM41 TUBA1A ZBTB7B ZBTB9 ZRANB1
Entrez ID		51043	94121
HPRD ID		09625	06735
Ensembl ID		ENSG00000160685	ENSG00000102362
Uniprot IDs		O15156	A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs			2CSZ 3FDW 5X6T
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of RNA Metabolic Process Phosphotyrosine Residue Binding Negative Regulation Of RNA Biosynthetic Process Type 2 Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Activation SH3 Domain Binding Small GTPase-mediated Signal Transduction DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleoplasm DNA Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lymphocyte Activation Positive Regulation Of Cell Adhesion Regulation Of DNA Recombination Regulation Of Cell-cell Adhesion Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Vesicle Membrane Non-canonical NF-kappaB Signal Transduction Cis-trans Isomerase Activity	Myosin V Binding Positive Regulation Of Exocytosis Regulation Of Synaptic Plasticity Exocytosis Vesicle-mediated Transport In Synapse Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Secretion By Cell Regulation Of Exocytosis Positive Regulation Of Secretion Modulation Of Chemical Synaptic Transmission Secretion Secretion By Cell Synaptic Vesicle Exocytosis Secretory Granule Regulated Exocytosis SNARE Complex Assembly Identical Protein Binding Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Synaptic Vesicle Regulation Of Secretion By Cell Positive Regulation Of Synaptic Transmission Positive Regulation Of Neurotransmitter Secretion Regulation Of Secretion Organelle Localization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neurotransmitter Secretion Neurotransmitter Transport Calcium-ion Regulated Exocytosis GTP Binding Regulation Of Vesicle Fusion Establishment Of Vesicle Localization Synaptic Vesicle Transport Vesicle Docking Involved In Exocytosis Postsynapse Regulation Of Calcium Ion-dependent Exocytosis Neurotransmitter Secretion Synaptic Vesicle Endocytosis Regulation Of Reactive Oxygen Species Biosynthetic Process Protein Transport Positive Regulation Of Transport Vesicle Localization Presynaptic Endocytosis Synaptic Vesicle Membrane Synaptic Vesicle Maturation Establishment Of Organelle Localization Regulation Of Cellular Component Organization Vesicle-mediated Transport Synapse
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