ZBTB7B and TRIP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZBTB7B	TRIP10
Description		zinc finger and BTB domain containing 7B	thyroid hormone receptor interactor 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II NK T Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ectoderm Development Lactation Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Interleukin-17 Production Response To Insulin Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of NK T Cell Proliferation Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Adaptive Thermogenesis Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of SREBP Signaling Pathway	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization
Pathways			Clathrin-mediated endocytosis RHOQ GTPase cycle
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Basal cell carcinoma ( 31174203) Bipolar disorder ( 31043756) Birth weight ( 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hip circumference adjusted for BMI ( 34021172) Keratinocyte cancer (MTAG) ( 31174203) Multiple sclerosis ( 31604244) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		27 interacting genes: BCL6 BCL6B CCNL2 CRBN EP300 FAM90A1 GRAP2 GRB2 IMP4 KPNA2 MORF4L2 NCK2 NDN OSTF1 PIN1 RELA RPL9 SH3KBP1 SH3YL1 SORBS3 SYTL4 TRIP10 UBTFL1 ZBTB42 ZBTB5 ZNF277 ZSCAN5B	43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B
Entrez ID		51043	9322
HPRD ID		09625	05142
Ensembl ID		ENSG00000160685	ENSG00000125733
Uniprot IDs		O15156	Q15642 W4VSQ9
PDB IDs			2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Regulation Of RNA Metabolic Process Phosphotyrosine Residue Binding Negative Regulation Of RNA Biosynthetic Process Type 2 Immune Response Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Chromatin DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of T Cell Activation SH3 Domain Binding Small GTPase-mediated Signal Transduction DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleoplasm DNA Binding Negative Regulation Of Mitotic Cell Cycle DNA Replication Regulation Of Lymphocyte Activation Positive Regulation Of Cell Adhesion Regulation Of DNA Recombination Regulation Of Cell-cell Adhesion Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity NF-kappaB Binding Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Endodermal Cell Differentiation Guanyl-nucleotide Exchange Factor Adaptor Activity Vesicle Membrane Non-canonical NF-kappaB Signal Transduction Cis-trans Isomerase Activity	Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette
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