KPNA4 and ADNP

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (biochemical, unspecified method)

		KPNA4	ADNP
Description		karyopherin subunit alpha 4	activity dependent neuroprotector homeobox
Image			No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex	Chromatin Extracellular Space Nucleus Chromosome Axon Dendrite Neuronal Cell Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Copper Ion Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Peptide Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide	Regulation Of Transcription By RNA Polymerase II Short-term Memory Response To Carbohydrate Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Neuron Projection Development CGMP-mediated Signaling Neuron Differentiation Intracellular Nitric Oxide Homeostasis Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of Axon Extension Negative Regulation Of Synaptic Transmission Neuron Apoptotic Process Positive Regulation Of Synapse Assembly Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)	Prostate cancer ( 25217961)
Interacting Genes		49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3	4 interacting genes: CDC27 H3-4 KPNA4 MAP1LC3B
Entrez ID		3840	23394
HPRD ID		04275	09793
Ensembl ID		ENSG00000186432	ENSG00000101126
Uniprot IDs		O00629	A0A2R8Y6X0 A0A669KBJ7 Q6DHZ8 Q9H2P0
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process	Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Mitotic Cell Cycle Dopamine Secretion Catecholamine Secretion NLS-dependent Protein Nuclear Import Complex D-glucose Transmembrane Transporter Activity L-ascorbic Acid Metabolic Process Response To Thyroglobulin Triiodothyronine Cellular Response To Starvation Fucose Transmembrane Transporter Activity Dehydroascorbic Acid Transport D-glucose Import Across Plasma Membrane Response To Starvation Long-chain Fatty Acid Import Across Plasma Membrane Cellular Response To Nutrient Levels Glucose Transporter Complex Dehydroascorbic Acid Transmembrane Transporter Activity Fucose Transmembrane Transport Female Pronucleus DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Cellular Response To Nitrogen Starvation Ceramide Binding Long-chain Fatty Acid Import Into Cell Lipid Import Into Cell Female Germ Cell Nucleus Phosphatidylethanolamine Binding Long-chain Fatty Acid Transmembrane Transporter Activity Protein-containing Complex Organization Anaphase-promoting Complex-dependent Catabolic Process Protein Branched Polyubiquitination Cell Division Anaphase-promoting Complex Positive Regulation Of Hippo Signaling Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Dopamine Transport Cellular Hyperosmotic Response D-glucose Import Xenobiotic Transmembrane Transporter Activity NLS-bearing Protein Import Into Nucleus Response To Nutrient Levels Hyperosmotic Response D-glucose Transmembrane Transport Monoamine Transport
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