KPNA4 and RANBP3

Number of citations of the paper that reports this interaction (PubMedID 37219487)
66

Data Source:
BioGRID (unspecified method)

		KPNA4	RANBP3
Description		karyopherin subunit alpha 4	RAN binding protein 3
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Small GTPase Binding R-SMAD Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide	Protein Export From Nucleus Protein Transport
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3	24 interacting genes: ANKS1A BLZF1 CHN2 GMCL1 GOLGA2 HOXA1 KLHL20 KPNA4 KPNB1 KPRP KRTAP1-3 KRTAP10-8 KRTAP13-1 KRTAP7-1 MEOX1 PAX6 PBX4 RAN RCC1 RGS20 TEPSIN TRAF2 XPO1 ZMIZ2
Entrez ID		3840	8498
HPRD ID		04275	04508
Ensembl ID		ENSG00000186432	ENSG00000031823
Uniprot IDs		O00629	B7Z7F3 Q53GE1 Q9H6Z4
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW	2CRF 2Y8F 2Y8G 5XZX
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process	Importin-alpha Family Protein Binding Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Spindle Organization RNA Import Into Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Spindle Organization Protein Localization To Nucleus NLS-dependent Protein Nuclear Import Complex HMG Box Domain Binding Nuclear Export Signal Receptor Activity Ribosomal Subunit Export From Nucleus Intermediate Filament Nuclear Pore Microtubule Cytoskeleton Organization Spindle Assembly Positive Regulation Of Hippo Signaling Nuclear Import Signal Receptor Activity Keratin Filament Nuclear Transport Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Chromatin Protein Transport NLS-bearing Protein Import Into Nucleus Establishment Of Organelle Localization Protein Import Into Nucleus Import Into Nucleus Protein Export From Nucleus Establishment Of Protein Localization Semicircular Canal Formation RNA Transport Forebrain-midbrain Boundary Formation Signal Transduction Involved In Regulation Of Gene Expression Pancreatic A Cell Development TORC2 Complex Disassembly Type II Interferon Binding Coated Vesicle Membrane Establishment Of Mitotic Spindle Localization Protein Localization To Organelle Mitotic Spindle Assembly Regulation Of Hippo Signaling Cytoskeleton Organization Intracellular Protein Localization Cis-Golgi Network Abducens Nerve Formation Optokinetic Behavior Establishment Of Spindle Localization Male Germ Cell Nucleus RNA Nuclear Export Complex
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