KPNA4 and SPRTN

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		KPNA4	SPRTN
Description		karyopherin subunit alpha 4	SprT-like N-terminal domain
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Speck
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide	DNA Repair Proteolysis DNA Damage Response Response To UV Protein Autoprocessing Translesion Synthesis Positive Regulation Of Protein Ubiquitination Interstrand Cross-link Repair Protein-DNA Covalent Cross-linking Repair
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Translesion Synthesis by POLH
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)	Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3	5 interacting genes: KPNA4 RNF11 UBC VCP VCPIP1
Entrez ID		3840	83932
HPRD ID		04275	13164
Ensembl ID		ENSG00000186432	ENSG00000010072
Uniprot IDs		O00629	Q9H040
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW	5IY4 6MDW 6MDX
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process	Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Hippo Signaling Proteolysis Protein Modification Process Modification-dependent Protein Catabolic Process Flavin Adenine Dinucleotide Catabolic Process Proteolysis Involved In Protein Catabolic Process VCP-NSFL1C Complex Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Positive Regulation Of Oxidative Phosphorylation Cytoplasm Protein Quality Control BAT3 Complex Binding Positive Regulation Of Protein Deubiquitination Golgi Reassembly Endoplasmic Reticulum Membrane Fusion Dopamine Secretion Macromolecule Metabolic Process Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Negative Regulation Of Protein Localization To Chromatin Macromolecule Catabolic Process Stress Granule Disassembly Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Deubiquitinase Activator Activity Catecholamine Secretion Derlin-1 Retrotranslocation Complex Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex NLS-dependent Protein Nuclear Import Complex Ubiquitin Protein Ligase Binding Regulation Of Protein Deubiquitination Positive Regulation Of Membrane Potential K48-linked Polyubiquitin Modification-dependent Protein Binding ATPase Complex Ubiquitin-modified Protein Reader Activity Cellular Response To Misfolded Protein Protein K11-linked Deubiquitination Protein Metabolic Process Positive Regulation Of Cellular Respiration Response To Misfolded Protein Positive Regulation Of ATP Biosynthetic Process Protein Tag Activity Endoplasmic Reticulum Membrane Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?