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KPNA4 and EXO1
Number of citations of the paper that reports this interaction (PubMedID
22222486
)
57
Data Source:
BioGRID
(pull down)
KPNA4
EXO1
Description
karyopherin subunit alpha 4
exonuclease 1
Image
GO Annotations
Cellular Component
Male Germ Cell Nucleus
Nucleus
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Membrane
NLS-dependent Protein Nuclear Import Complex
Nucleus
Nucleoplasm
Plasma Membrane
Nuclear Body
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
DNA Binding
Chromatin Binding
Catalytic Activity
Nuclease Activity
Endonuclease Activity
DNA Endonuclease Activity
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
Hydrolase Activity
Hydrolase Activity, Acting On Ester Bonds
5'-flap Endonuclease Activity
5'-3' DNA Exonuclease Activity
Single-stranded DNA 5'-3' DNA Exonuclease Activity
Metal Ion Binding
Flap Endonuclease Activity
Double-stranded DNA 5'-3' DNA Exonuclease Activity
Biological Process
Protein Import Into Nucleus
NLS-bearing Protein Import Into Nucleus
Gene Expression
Dopamine Secretion
Protein Transport
Positive Regulation Of Hippo Signaling
Response To Hydrogen Peroxide
Immune System Process
Humoral Immune Response Mediated By Circulating Immunoglobulin
DNA Repair
Mismatch Repair
DNA Recombination
DNA Damage Response
Somatic Hypermutation Of Immunoglobulin Genes
Isotype Switching
Meiotic Cell Cycle
T-circle Formation
DNA Strand Resection Involved In Replication Fork Processing
Pathways
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33547301
)
Alcohol use disorder (total score) (
30336701
)
Aspartate aminotransferase levels (
33547301
)
Attention deficit hyperactivity disorder (
32279069
)
Bipolar disorder (
31043756
)
Malaria (
31844061
)
Myeloproliferative neoplasms (
33057200
)
Pit-and-Fissure caries (
24556642
)
Post bronchodilator FEV1 (
26634245
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Smooth-surface caries (
24556642
)
Total cholesterol levels (
30275531
)
Basal cell carcinoma (
31174203
)
Breast cancer (
25751625
29059683
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Keratinocyte cancer (MTAG) (
31174203
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Menopause (age at onset) (
22267201
26414677
)
Interacting Genes
49 interacting genes:
ADNP
AFF2
APP
CDKN1B
CFAP298
CSE1L
CSNK2A1
CTDSPL2
CUL4B
DMTF1
DYRK1A
EXO1
FAM50B
GTF2IRD1
HIF1A
HJURP
HNRNPC
HSD3B7
KAT5
KDR
MAT2B
MEF2C
MORC3
MRTFB
MTA1
NCBP3
NCOR2
NFE2L2
NKX2-5
NRIP1
NTRK3
OGT
PLAA
PLEKHG4B
RAC1
RANBP3
RECQL
RNF38
RYBP
SCAND3
SPRTN
SQSTM1
TGM2
TPX2
WT1
ZFTRAF1
ZMIZ2
ZNF532
ZRANB3
20 interacting genes:
ATM
BLM
DCAF1
H4C1
KPNA4
KPNB1
MLH1
MLH3
MSH2
MSH3
PCNA
PMS2
SENP6
SFN
UBE2I
YWHAB
YWHAE
YWHAG
YWHAH
YWHAZ
Entrez ID
3840
9156
HPRD ID
04275
06932
Ensembl ID
ENSG00000186432
ENSG00000174371
Uniprot IDs
O00629
A8K5H6
Q9UQ84
PDB IDs
4UAE
5TBK
5XZX
6BVV
6BVZ
6BW9
6BWA
6BWB
6WX8
7JJL
7LF4
7LFC
7RFY
7RG5
8FUB
8FZM
8HKW
3QE9
3QEA
3QEB
5UZV
5V04
5V05
5V06
5V07
5V08
5V09
5V0A
5V0B
5V0C
5V0D
5V0E
7MXQ
7MXR
7MXS
7MXT
7MXU
7MXV
7MXW
7MXX
Enriched GO Terms of Interacting Partners
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Nucleus
Nucleoplasm
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Gene Expression
Rhythmic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Modification Process
Negative Regulation Of DNA-templated Transcription
Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of MiRNA Transcription
Positive Regulation Of Developmental Process
Chromatin Organization
Regulation Of Developmental Growth
Apoptotic Process
Regulation Of MiRNA Metabolic Process
Regulation Of Cellular Component Organization
Regulation Of Growth
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Chromatin
Regulation Of Synapse Assembly
Aggrephagy
Protein Targeting To Vacuole Involved In Autophagy
Programmed Cell Death
Cell Death
Regulation Of Cell Junction Assembly
DNA Binding
DNA Repair
Epithelial Tube Morphogenesis
Regulation Of Synapse Organization
Positive Regulation Of Catabolic Process
Mismatch Repair
Mismatched DNA Binding
Somatic Cell DNA Recombination
ATP-dependent DNA Damage Sensor Activity
Phosphoserine Residue Binding
DNA Recombination
Protein Sequestering Activity
Dinucleotide Insertion Or Deletion Binding
Chromosome Organization
Negative Regulation Of DNA Recombination
Guanine/thymine Mispair Binding
Enzyme Binding
Regulation Of DNA Recombination
Mismatch Repair Complex
Cellular Response To Stress
Positive Regulation Of Isotype Switching To IgA Isotypes
DNA Metabolic Process
DNA Repair
Somatic Recombination Of Immunoglobulin Gene Segments
Nucleus
DNA Damage Response
Single-stranded DNA Binding
Protein Domain Specific Binding
Somatic Diversification Of Immunoglobulins
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Isotype Switching To IgG Isotypes
Male Germ Cell Nucleus
Somatic Hypermutation Of Immunoglobulin Genes
Negative Regulation Of DNA Metabolic Process
Somatic Diversification Of Immune Receptors Via Somatic Mutation
Regulation Of Isotype Switching To IgG Isotypes
Regulation Of DNA Metabolic Process
Intracellular Protein Localization
Nucleoplasm
Chiasma
MutSbeta Complex
Dinucleotide Repeat Insertion Binding
Chromosome, Telomeric Region
Positive Regulation Of Hippo Signaling
Positive Regulation Of DNA Recombination
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Synaptonemal Complex
Protein Kinase C Inhibitor Activity
MutLalpha Complex
Single Guanine Insertion Binding
Response To X-ray
Reciprocal Meiotic Recombination
Positive Regulation Of Isotype Switching
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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