KPNA4 and CFAP298

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		KPNA4	CFAP298
Description		karyopherin subunit alpha 4	cilia and flagella associated protein 298
Image			No pdb structure
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide	Regulation Of Cilium Movement Cilium Assembly
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)
Interacting Genes		49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3	21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624
Entrez ID		3840	56683
HPRD ID		04275	10756
Ensembl ID		ENSG00000186432	ENSG00000159079
Uniprot IDs		O00629	C9J818 D3DSE6 P57076
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process	Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process
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