KPNA4 and PLAA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KPNA4	PLAA
Description		karyopherin subunit alpha 4	phospholipase A2 activating protein
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GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Membrane NLS-dependent Protein Nuclear Import Complex	Nucleus Cytoplasm Synapse Extracellular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding Phospholipase A2 Activator Activity Ubiquitin Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Gene Expression Dopamine Secretion Protein Transport Positive Regulation Of Hippo Signaling Response To Hydrogen Peroxide	Lipid Metabolic Process Phospholipid Metabolic Process Inflammatory Response Signal Transduction Nervous System Development Ubiquitin Recycling Macroautophagy Positive Regulation Of Prostaglandin Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Dendrite Extension Positive Regulation Of Neuron Migration
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alcohol use disorder (total score) ( 30336701) Aspartate aminotransferase levels ( 33547301) Attention deficit hyperactivity disorder ( 32279069) Bipolar disorder ( 31043756) Malaria ( 31844061) Myeloproliferative neoplasms ( 33057200) Pit-and-Fissure caries ( 24556642) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Smooth-surface caries ( 24556642) Total cholesterol levels ( 30275531)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Metabolite levels ( 23823483) Schizophrenia ( 20185149)
Interacting Genes		49 interacting genes: ADNP AFF2 APP CDKN1B CFAP298 CSE1L CSNK2A1 CTDSPL2 CUL4B DMTF1 DYRK1A EXO1 FAM50B GTF2IRD1 HIF1A HJURP HNRNPC HSD3B7 KAT5 KDR MAT2B MEF2C MORC3 MRTFB MTA1 NCBP3 NCOR2 NFE2L2 NKX2-5 NRIP1 NTRK3 OGT PLAA PLEKHG4B RAC1 RANBP3 RECQL RNF38 RYBP SCAND3 SPRTN SQSTM1 TGM2 TPX2 WT1 ZFTRAF1 ZMIZ2 ZNF532 ZRANB3	6 interacting genes: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP
Entrez ID		3840	9373
HPRD ID		04275	04850
Ensembl ID		ENSG00000186432	ENSG00000137055
Uniprot IDs		O00629	Q9Y263
PDB IDs		4UAE 5TBK 5XZX 6BVV 6BVZ 6BW9 6BWA 6BWB 6WX8 7JJL 7LF4 7LFC 7RFY 7RG5 8FUB 8FZM 8HKW	2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Rhythmic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Regulation Of Programmed Cell Death Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Transcription Positive Regulation Of Developmental Process Chromatin Organization Regulation Of Developmental Growth Apoptotic Process Regulation Of MiRNA Metabolic Process Regulation Of Cellular Component Organization Regulation Of Growth Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Chromatin Regulation Of Synapse Assembly Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Programmed Cell Death Cell Death Regulation Of Cell Junction Assembly DNA Binding DNA Repair Epithelial Tube Morphogenesis Regulation Of Synapse Organization Positive Regulation Of Catabolic Process	Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Aggresome Assembly Regulation Of Protein Deubiquitination K48-linked Polyubiquitin Modification-dependent Protein Binding Inclusion Body Assembly VCP-NPL4-UFD1 AAA ATPase Complex Cellular Response To Misfolded Protein Response To Misfolded Protein Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Catabolic Process Regulation Of Hippo Signaling Cellular Response To Heat Macromolecule Catabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteolysis Flavin Adenine Dinucleotide Catabolic Process Organelle Disassembly Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Response To Heat Response To Hydrogen Peroxide Intracellular Protein Transport Positive Regulation Of Podocyte Apoptotic Process VCP-NSFL1C Complex Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of Protein K63-linked Deubiquitination Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Ubiquitin Binding Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity K6-linked Polyubiquitin Modification-dependent Protein Binding Proteasome Regulatory Particle Binding Negative Regulation Of Protein K48-linked Deubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Arsenite Ion Mitotic Spindle Disassembly Protein-containing Complex Disassembly Positive Regulation Of Oxidative Phosphorylation
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