KPNA4 and PLAA

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KPNA4	PLAA
Gene Name		karyopherin alpha 4 (importin alpha 3)	phospholipase A2-activating protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Vesicular Exosome	Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Transporter Activity	Protein Binding Phospholipase A2 Activator Activity
	Biological Process	NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Response To Hydrogen Peroxide	Phospholipid Metabolic Process Inflammatory Response Signal Transduction Positive Regulation Of Catalytic Activity
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS			Schizophrenia ( 20185149)
Protein-Protein Interactions		17 interactors: APP CDKN1B CSE1L CSNK2A1 CUL4B CYHR1 EXO1 HNRNPC KPNB1 MAT2B NUP50 PLAA RAC1 RCC1 RECQL TGM2 TP53	6 interactors: HDAC6 KPNA4 PLA2G1B UBC UBXN1 VCP
Entrez ID		3840	9373
HPRD ID		04275	04850
Ensembl ID		ENSG00000186432	ENSG00000137055
Uniprot IDs		O00629	Q9Y263
PDB IDs			2K89 2K8A 2K8B 2K8C 3EBB
Enriched GO Terms of Interacting Partners?		Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Process Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Cell Cycle Process Cell Cycle Cellular Response To Stimulus Regulation Of Cell Cycle Viral Process Positive Regulation Of Cell Cycle DNA Strand Renaturation Mitotic Cell Cycle Arrest Regulation Of Catalytic Activity Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Checkpoint Response To Stimulus Protein Import Into Nucleus, Translocation Nucleobase-containing Compound Metabolic Process Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein Complex Assembly Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Organelle Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Cell Surface Receptor Signaling Pathway Cell Cycle Process Cell Cycle Checkpoint DNA Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Abiotic Stimulus Regulation Of Growth Positive Regulation Of Cell Death DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Neuron Apoptotic Process See more	Aggresome Assembly Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Proteolysis Catabolic Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Protein Catabolic Process Cellular Response To Heat Intracellular Transport Proteolysis Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Lys63-specific Deubiquitinase Activity Positive Regulation Of Protein K63-linked Deubiquitination Hsp90 Deacetylation Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Programmed Cell Death Cellular Response To Topologically Incorrect Protein Protein Modification By Small Protein Conjugation Positive Regulation Of Cell Death Response To Heat Response To Stress Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Hydrogen Peroxide Positive Regulation Of Chaperone-mediated Protein Complex Assembly Polyubiquitinated Misfolded Protein Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Activation Of MAPK Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Establishment Of Localization In Cell Protein Polyubiquitination Multicellular Organismal Lipid Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Complex Assembly Response To Temperature Stimulus Interleukin-8 Production Activation Of Phospholipase A2 Activity Negative Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process See more
Tagcloud ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Difference) ?		9k arrb1 atg14 atg4b cage1 cald1 cd9 chrna7 chrnb1 col1 expressional fn1 frap hey1 humn il10r il12 il13 il15 il27 immunochemical informational oas slc6a2 vegfc villi villous villus voluntarily	a1 a11 anxa1 anxa11 assignment connections correct cst4 cystatin discriminated discriminative discriminatory dry eye fifteen maldi meibomian merocel multiplexed ocular overlapping page proteome roc s100a6 sponge tear tof validation
Tagcloud (Intersection) ?