SLC26A3 and SLC9A3R2

Number of citations of the paper that reports this interaction (PMID 12369822)
23

Data Source:
BioGRID (pull down)

		SLC26A3	SLC9A3R2
Gene Name		solute carrier family 26 (anion exchanger), member 3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Sperm Midpiece	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Endomembrane System Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Transporter Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Anion:anion Antiporter Activity	Receptor Binding Protein Binding Beta-catenin Binding Protein C-terminus Binding Phosphatase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Ion Transport Anion Transport Excretion Bicarbonate Transport Sperm Capacitation Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Cellular Response To CAMP Sulfate Transmembrane Transport Chloride Transmembrane Transport Regulation Of Nucleic Acid-templated Transcription	Protein Complex Assembly Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Multifunctional anion exchangers SLC-mediated transmembrane transport
Drugs
Diseases
GWAS		Ulcerative colitis ( 19915573 19122664)
Protein-Protein Interactions		2 interactors: SLC9A3R1 SLC9A3R2	35 interactors: ABCC4 ACTN4 ADORA2B ADRB2 ATP2B2 CFTR EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDPK1 PDZK1 PIK3CA PLCB3 PODXL PRKACA PTEN PTH1R RDX SGK1 SGK3 SIAH1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAZ TBC1D10A WWTR1
Entrez ID		1811	9351
HPRD ID		00544	05946
Ensembl ID		ENSG00000091138	ENSG00000065054
Uniprot IDs		P40879	Q15599
PDB IDs			2D11 2HE4 2OCS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Phosphatidylinositol 3-kinase Signaling Renal Phosphate Ion Absorption Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Intracellular Signal Transduction Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Complex Assembly Regulation Of Excretion Negative Regulation Of Signal Transduction Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Signaling Bile Acid And Bile Salt Transport Dopamine Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Transporter Activity Anion Homeostasis Negative Regulation Of Ion Transmembrane Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Transmembrane Transport Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Acid Secretion Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Sodium Ion Transport Regulation Of Intracellular Signal Transduction Cellular Component Assembly Peptide Transport Negative Regulation Of Ion Transport Renal System Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Kinase B Signaling Amide Transport	Regulation Of Protein Kinase Activity Ion Homeostasis Transmembrane Transport Regulation Of Kinase Activity Regulation Of Ion Transport Positive Regulation Of Ion Transport Regulation Of Protein Phosphorylation Homeostatic Process Positive Regulation Of Transport Ion Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Phosphorylation Ion Transmembrane Transport Cellular Cation Homeostasis Organic Anion Transport Cellular Ion Homeostasis Cytosolic Calcium Ion Homeostasis Chemical Homeostasis Positive Regulation Of Protein Kinase Activity Blood Circulation Positive Regulation Of Cellular Protein Metabolic Process Anion Transport Platelet Activation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Transport Positive Regulation Of Protein Phosphorylation Sodium-independent Organic Anion Transport Carnitine Transport Cellular Chemical Homeostasis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Body Fluid Levels Monocarboxylic Acid Transport Sperm Capacitation Anion Transmembrane Transport Regulation Of Cellular Component Organization Sodium Ion Transport Inorganic Anion Transport Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Quaternary Ammonium Group Transport Positive Regulation Of Cytosolic Calcium Ion Concentration
Tagcloud ?		anhydrase aqp3 aquaglyceroporin3 carbachol carbonic clostridium colonic colonizing compliant doubled electrolyte elicits faecalis fusobacterium germfree gf goblet innocuum intestinalis lactobacillus microbiotas monocolonized mucin mucus pioneer resides shortly simplified suckling
Tagcloud (Difference) ?		anhydrase aqp3 aquaglyceroporin3 carbachol carbonic clostridium colonic colonizing compliant doubled electrolyte elicits faecalis fusobacterium germfree gf goblet innocuum intestinalis lactobacillus microbiotas monocolonized mucin mucus pioneer resides shortly simplified suckling
Tagcloud (Intersection) ?