EFTUD2 and LSM8

Number of citations of the paper that reports this interaction (PubMedID 28515276)
62

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		EFTUD2	LSM8
Description		elongation factor Tu GTP binding domain containing 2	LSM8 homolog, U6 small nuclear RNA associated
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding U5 SnRNA Binding	RNA Binding MRNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Response To Cocaine Cellular Response To Xenobiotic Stimulus	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31619474) Craniofacial microsomia ( 26853712)	Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Smoking initiation ( 33082346) Smoking status (current vs never) ( 33082346) Triglyceride levels ( 30108155)
Interacting Genes		15 interacting genes: ARPC3 CYFIP1 DUX4 GOLM1 GSK3B HINFP LSM8 PIN1 PRPF6 SF3B3 SF3B4 SREK1 SUMO2 USP7 WBP4	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		9343	51691
HPRD ID		04869	06288
Ensembl ID		ENSG00000108883	ENSG00000128534
Uniprot IDs		B3KX19 Q15029	A4D0W0 O95777
PDB IDs		3JCR 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6ZYM 7AAV 7ABF 7ABG 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8Q7Q 8Q7V 8Q7W 8Q7X 8Q91 8QO9 8QOZ 8QP8 8QP9 8QPA 8QPB 8QPE 8QPK 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RC0 8RM5 8RO2 8Y6O 9FMD	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 7ABG 8H6E 8H6J 8H6K 8H6L 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5
Enriched GO Terms of Interacting Partners?		U2-type Precatalytic Spliceosome Spliceosomal Complex MRNA Splicing, Via Spliceosome Precatalytic Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Processing Negative Regulation Of Protein Catabolic Process Spliceosomal Complex Assembly MRNA Metabolic Process Nucleoplasm Regulation Of Protein Catabolic Process RNA Processing RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleic Acid Metabolic Process U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process U2 SnRNP Postsynaptic Cytosol U2-type Spliceosomal Complex Negative Regulation Of Catabolic Process Positive Regulation Of RNA Biosynthetic Process Nucleus Positive Regulation Of DNA-templated Transcription Regulation Of Ubiquitin-dependent Protein Catabolic Process Nuclear Speck Cellular Component Assembly Positive Regulation Of Transcription By RNA Polymerase II U4/U6 X U5 Tri-snRNP Complex Positive Regulation Of RNA Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Tau Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Regulation Of Microtubule Anchoring At Centrosome Cis-trans Isomerase Activity Growth Cone Leading Edge Protein-RNA Complex Assembly Nucleobase-containing Compound Metabolic Process Postsynapse Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Leading Edge Glutamatergic Synapse Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Nucleic Acid Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development	U2-type Precatalytic Spliceosome U4/U6 X U5 Tri-snRNP Complex Lsm2-8 Complex MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions U6 SnRNP MRNA Catabolic Process Spliceosomal Complex Lsm1-7-Pat1 Complex RNA Catabolic Process RNA Splicing Catalytic Step 2 Spliceosome Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Processing RNA Processing RNA Binding Ribonucleoprotein Complex Small Nuclear Ribonucleoprotein Complex Precatalytic Spliceosome P-body Nucleobase-containing Compound Catabolic Process Nuclear-transcribed MRNA Catabolic Process Nucleic Acid Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Protein-RNA Complex Assembly Double-stranded DNA Helicase Activity U5 SnRNP Positive Regulation Of MRNA Cis Splicing, Via Spliceosome U12-type Spliceosomal Complex Deadenylation-independent Decapping Of Nuclear-transcribed MRNA U2-type Catalytic Step 2 Spliceosome Spliceosomal Tri-snRNP Complex U1 SnRNP Binding Nucleoplasm Poly(A)-dependent SnoRNA 3'-end Processing 7-methylguanosine Cap Hypermethylation Spliceosomal SnRNP Assembly Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Nucleolar Exosome (RNase Complex) 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Nuclear MRNA Surveillance U4 SnRNP Methylosome Macromolecule Metabolic Process Pentose-phosphate Shunt Regulation Of MRNA Processing Septin Ring
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