MVB12A and SH3KBP1

Number of citations of the paper that reports this interaction (PMID 16895919)
7

Data Source:
HPRD (in vivo)

		MVB12A	SH3KBP1
Gene Name		multivesicular body subunit 12A	SH3-domain kinase binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Aggresome Late Endosome Membrane Vesicle Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding	Protein Binding SH3 Domain Binding
	Biological Process	Protein Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Endocytosis Apoptotic Process Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Cell Migration Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: APP CD2AP SH3KBP1 TSG101 UBC	45 interactors: ABI2 ARAP1 ARHGAP27 ASAP1 ASAP2 BCAR1 BLNK BMPR1B CAPZA1 CBL CBLB CD2 GRB2 HCK INPP5D ITSN2 LMNA MVB12A NEDD4 PAK2 PDCD6 PDCD6IP PIK3CA PIK3R1 PNMA5 PSMA3 SH3BP2 SH3GL2 SH3GL3 SH3GLB1 SH3GLB2 SHKBP1 SOS1 SPRY2 STAP1 SUMO1 SUMO2 SUMO3 SYNJ1 TAF6 TJP2 UBB UBC ZBTB7B ZNF219
Entrez ID		93343	30011
HPRD ID		14298	02301
Ensembl ID		ENSG00000141971	ENSG00000147010
Uniprot IDs		Q96EY5	B7Z6E8 Q5JPT6 Q96B97
PDB IDs			2BZ8 2K6D 2K9G 2O2O 2YDL
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Viral Protein Processing Virion Assembly Intracellular Transport Of Virus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Notch Signaling Pathway Synaptic Growth At Neuromuscular Junction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Negative Regulation Of Transforming Growth Factor Beta1 Production Viral Life Cycle Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Endosomal Transport Negative Regulation Of Cytokine Production Cell Cycle Process Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Protein Processing Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Extracellular Vesicular Exosome Assembly Axon Choice Point Recognition Locomotion Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Cell Cycle Viral Budding Neuron Remodeling Vesicle-mediated Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Movement Of Cell Or Subcellular Component Intracellular Transport Substrate-dependent Cell Migration, Cell Extension Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Cellular Copper Ion Homeostasis	Regulation Of Signal Transduction Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Cellular Process Signaling Signal Transduction Cell Communication Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Response To Fibroblast Growth Factor Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process Regulation Of Cell Death Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway Apoptotic Process Immune System Process Programmed Cell Death Cellular Response To Stimulus Cell Death Death Fc Receptor Signaling Pathway Immune Response Viral Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Endocytosis Locomotion Movement Of Cell Or Subcellular Component Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Catalytic Activity Regulation Of Immune Response
Tagcloud ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?			calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 ptch2 sam68 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?