MVB12A and CD2AP

Number of citations of the paper that reports this interaction (PMID 16895919)
7

Data Source:
HPRD (in vivo)

		MVB12A	CD2AP
Gene Name		multivesicular body subunit 12A	CD2-associated protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	ESCRT I Complex Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Aggresome Late Endosome Membrane Vesicle Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Ruffle Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Actin Cytoskeleton Filamentous Actin Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding	Structural Constituent Of Cytoskeleton Protein Binding SH3 Domain Binding
	Biological Process	Protein Transport Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway	Protein Complex Assembly Substrate-dependent Cell Migration, Cell Extension Mitotic Nuclear Division Signal Transduction Negative Regulation Of Transforming Growth Factor Beta1 Production Cell Division Positive Regulation Of Protein Localization To Nucleus Regulation Of Actin Cytoskeleton Reorganization
Pathways			Nephrin interactions
Drugs
Diseases
GWAS			Alzheimer's disease (late onset) ( 21460841)
Protein-Protein Interactions		5 interactors: APP CD2AP SH3KBP1 TSG101 UBC	30 interactors: BCAR1 CAPZA1 CBL CD2 CTTN FYN GRB2 GZMB HBP1 HCK HOXC11 KHDRBS1 MVB12A NPHS1 NPHS2 NR2C2 NR4A1 PDCD6IP PIK3R1 PKD2 PSTPIP1 PTGES3 RAB4A SH3GL2 SOS1 SOS2 SRC UBC WTIP YES1
Entrez ID		93343	23607
HPRD ID		14298	05026
Ensembl ID		ENSG00000141971	ENSG00000198087
Uniprot IDs		Q96EY5	Q9Y5K6
PDB IDs			2FEI 2J6F 2J6K 2J6O 2J7I 3AA6 3LK4 3U23
Enriched GO Terms of Interacting Partners?		Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Viral Protein Processing Virion Assembly Intracellular Transport Of Virus Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Notch Signaling Pathway Synaptic Growth At Neuromuscular Junction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Cell Cycle Collateral Sprouting In Absence Of Injury Negative Regulation Of Transforming Growth Factor Beta1 Production Viral Life Cycle Apoptotic Process Intracellular Receptor Signaling Pathway Programmed Cell Death Endosomal Transport Negative Regulation Of Cytokine Production Cell Cycle Process Cell Death Death Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Collateral Sprouting Axon Midline Choice Point Recognition Protein Processing Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Transforming Growth Factor Beta Production Regulation Of Extracellular Vesicular Exosome Assembly Axon Choice Point Recognition Locomotion Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Cell Cycle Viral Budding Neuron Remodeling Vesicle-mediated Transport Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Movement Of Cell Or Subcellular Component Intracellular Transport Substrate-dependent Cell Migration, Cell Extension Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Cell Cycle Cellular Copper Ion Homeostasis	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Regulation Of Cellular Component Organization Cell Communication Signal Transduction Leukocyte Migration Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Movement Of Cell Or Subcellular Component Regulation Of ERBB Signaling Pathway Locomotion Cellular Response To Hormone Stimulus Cellular Response To Organic Substance Blood Coagulation Hemostasis Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Migration Cellular Response To Peptide Hormone Stimulus Regulation Of Immune Response Cellular Response To Peptide Cell Motility Response To Organic Substance Immune Response Regulation Of Immune System Process Regulation Of Body Fluid Levels Positive Regulation Of Organelle Organization Regulation Of Cellular Process Cellular Response To Stimulus Wound Healing Chemotaxis T Cell Costimulation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Response To Stimulus
Tagcloud ?			abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Difference) ?			abca7 bin1 cass4 cd33 celf1 chapter discoveries drb1 drb5 epha1 fermt2 inpp5d mef2c ms4a4 ms4a6 nme8 picalm pld3 psen1 psen2 ptk2b rin3 slc24a4 sorl1 touch trem2 trip4 unsuspected zcwpw1
Tagcloud (Intersection) ?