MVB12A and PPP1R27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MVB12A	PPP1R27
Description		multivesicular body subunit 12A	protein phosphatase 1 regulatory subunit 27
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleus Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Endosome Membrane Membrane Late Endosome Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Lipid Binding SH3 Domain Binding Ubiquitin Binding	Protein Phosphatase Inhibitor Activity Protein Binding Phosphatase Binding
	Biological Process	Protein Transport Macroautophagy Virus Maturation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Receptor Catabolic Process Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Viral Budding Membrane Fission
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: APP CD2AP HSF2BP OXTR PPP1R27 SH3KBP1 SNCA UBC	9 interacting genes: DDIT4L GCC1 KRT34 MVB12A NTAQ1 PPP1CA PPP1CB RPL9 SMCP
Entrez ID		93343	116729
HPRD ID		14298	17334
Ensembl ID		ENSG00000141971	ENSG00000182676
Uniprot IDs		Q96EY5	Q86WC6
PDB IDs		6VME
Enriched GO Terms of Interacting Partners?		Collateral Sprouting Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Regulation Of Presynapse Assembly Regulation Of Neurotransmitter Uptake Nuclear Envelope Lumen Cellular Response To Copper Ion Supramolecular Fiber Organization Regulation Of Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Response To Copper Ion Leukocyte Activation Involved In Inflammatory Response Regulation Of Neuron Apoptotic Process Protein Complex Oligomerization Synapse Organization Amyloid-beta Complex Regulation Of Neuronal Synaptic Plasticity Apoptotic Process Growth Cone Lamellipodium Neuron Projection Regulation Of Response To Calcium Ion Macrophage Activation Response To Growth Factor Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Oxytocin Receptor Activity Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Programmed Cell Death Cell Death Adult Locomotory Behavior Response To Interleukin-1 Axon Acetylcholine Receptor Activator Activity Protein Tetramerization Endocytosis Lipoprotein Particle Positive Regulation Of Protein Import Positive Regulation Of Protein Localization Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Cell Junction Organization PTB Domain Binding	PTW/PP1 Phosphatase Complex Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Circadian Regulation Of Gene Expression Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Myosin-light-chain-phosphatase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Phosphatase Activity Protein Dephosphorylation RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Virus Maturation Regulation Of Circadian Rhythm Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Termination Of DNA-templated Transcription Dephosphorylation Positive Regulation Of Termination Of RNA Polymerase II Transcription Circadian Rhythm Myosin Phosphatase Activity Phosphoprotein Phosphatase Activity Glycogen Granule RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Energy Derivation By Oxidation Of Organic Compounds Chromosome, Telomeric Region Golgi Trans Cisterna Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Cytoplasm Double-strand Break Repair Via Alternative Nonhomologous End Joining Penetration Of Zona Pellucida Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cytosol ESCRT I Complex
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