ZNHIT3 and XRCC3

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNHIT3	XRCC3
Gene Name		zinc finger, HIT-type containing 3	X-ray repair complementing defective repair in Chinese hamster cells 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular	Nucleus Replication Fork Cytoplasm Mitochondrion Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Metal Ion Binding Thyroid Hormone Receptor Binding	Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Regulation Of Transcription, DNA-templated	Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CSNK2A2 ESR2 FAIM3 HNF4A MBNL1 MEIS2 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24	6 interactors: FANCG RAD51C RAD51D SWSAP1 ZNHIT3 ZSWIM7
Entrez ID		9326	7517
HPRD ID		05139	07201
Ensembl ID		ENSG00000108278	ENSG00000126215
Uniprot IDs		K7EQP1 Q15649	O43542 Q53XC8
PDB IDs		2YQQ
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription, DNA-templated RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Nucleobase-containing Compound Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process System Development Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Organ Development Peroxisome Proliferator Activated Receptor Signaling Pathway Developmental Process Response To Hormone Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Developmental Process Involved In Reproduction Reproductive Process	Double-strand Break Repair Via Homologous Recombination Recombinational Repair Double-strand Break Repair DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Reciprocal Meiotic Recombination Protein Stabilization Meiosis I Response To Stress Female Meiosis Sister Chromatid Cohesion Strand Invasion Regulation Of Protein Stability Meiotic Nuclear Division Meiotic Cell Cycle Nucleobase-containing Compound Metabolic Process Meiotic Sister Chromatid Cohesion Reproduction Cell Cycle Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Nitrogen Compound Metabolic Process Posttranscriptional Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Spermatogenesis Male Gamete Generation Sister Chromatid Cohesion Male Meiosis I Cellular Response To Stimulus Female Meiotic Division Gamete Generation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Male Meiosis Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Ovarian Follicle Development Telomere Maintenance Meiotic Chromosome Segregation Response To Stimulus Sister Chromatid Segregation DNA Catabolic Process, Endonucleolytic Chromosome Organization
Tagcloud ?		5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload	additive allele applying became bonferroni correction d312n damaged dominant ercc2 ethnical exoi gg insignificant polymorphism polymorphisms r399q recessive remaining repair rs1799793 rs25487 russian russians snps tt xrcc1 xrcc2
Tagcloud (Difference) ?		5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload	additive allele applying became bonferroni correction d312n damaged dominant ercc2 ethnical exoi gg insignificant polymorphism polymorphisms r399q recessive remaining repair rs1799793 rs25487 russian russians snps tt xrcc1 xrcc2
Tagcloud (Intersection) ?