ZNHIT3 and THRB

Number of citations of the paper that reports this interaction (PMID 7776974)
105

Data Source:
HPRD (two hybrid)

		ZNHIT3	THRB
Gene Name		zinc finger, HIT-type containing 3	thyroid hormone receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Intracellular	Nuclear Chromatin Nucleus Nucleoplasm Extracellular Vesicular Exosome
	Molecular Function	Metal Ion Binding Thyroid Hormone Receptor Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Corepressor Activity Thyroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Sequence-specific DNA Binding Thyroid Hormone Binding
	Biological Process	Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Organ Morphogenesis Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Type I Pneumocyte Differentiation
Pathways			Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Liothyronine Levothyroxine Dextrothyroxine Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione [4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]-Acetic Acid GC-24 {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE
Diseases
GWAS			Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell traits ( 23222517)
Protein-Protein Interactions		13 interactors: CSNK2A2 ESR2 FAIM3 HNF4A MBNL1 MEIS2 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24	58 interactors: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF EIF3I ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 ZNHIT3
Entrez ID		9326	7068
HPRD ID		05139	07521
Ensembl ID		ENSG00000108278	ENSG00000151090
Uniprot IDs		K7EQP1 Q15649	F1D8N7 P10828
PDB IDs		2YQQ	1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription, DNA-templated RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Steroid Hormone Stimulus Nucleobase-containing Compound Metabolic Process Gene Expression Intracellular Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process System Development Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Multicellular Organismal Development Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Lipid Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Lipid Negative Regulation Of Cellular Metabolic Process Response To Steroid Hormone Organ Development Peroxisome Proliferator Activated Receptor Signaling Pathway Developmental Process Response To Hormone Regulation Of Transcription, DNA-templated Epithelial Cell Differentiation Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Developmental Process Involved In Reproduction Reproductive Process	Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Intracellular Receptor Signaling Pathway RNA Metabolic Process Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Chromatin Organization Chromosome Organization Transcription Initiation From RNA Polymerase II Promoter Response To Hormone Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Metabolic Process Chromatin Modification Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Cellular Process Cellular Response To Stimulus Response To Steroid Hormone
Tagcloud ?		5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Difference) ?		5k adenosine applies assembly bcd1 box core existence gets hsp90 isotope nop58 nucleolar nufip premature proteomic r2tp ribonucleoproteins rsa1p ruvbl scheme sequential snornas snornp snornps snu13p triphosphatase unexpected unload	approximate bank carrying circular clarke clockwise ecori enabled endonuclease hybird kilobase kilobases lacz lambda limitation maxicell pbr322 phage pho phom phou plac plasmid plasmids plc17 regulon subcloned threefold transcribed
Tagcloud (Intersection) ?