ZNHIT3 and MBNL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ZNHIT3	MBNL1
Description		zinc finger HIT-type containing 3	muscleblind like splicing regulator 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Pre-snoRNP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Nuclear Thyroid Hormone Receptor Binding	RNA Binding Double-stranded RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Box C/D SnoRNP Assembly Regulation Of DNA-templated Transcription	In Utero Embryonic Development MRNA Processing Nervous System Development RNA Splicing Embryonic Limb Morphogenesis Regulation Of RNA Splicing Myoblast Differentiation
Pathways
Drugs
Diseases
GWAS		Body mass index ( 26426971) Multiple sclerosis ( 31604244) Red cell distribution width ( 27863252 28957414 32888494)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Blond vs. brown/black hair color ( 30531825) End-stage renal disease ( 29885931) Fasting glucose ( 34059833) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Infantile hypertrophic pyloric stenosis ( 22306654) Liver enzyme levels (alanine transaminase) ( 33972514) Male-pattern baldness ( 27182965) Prostate cancer ( 29892016) Type 2 diabetes ( 30054458 30297969 32499647) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) White blood cell count ( 32888494)
Interacting Genes		13 interacting genes: CSNK2A2 ESR2 FCMR HNF4A MBNL1 MEIS2 PBX3 PITX2 PPARG RXRA THRB XRCC3 ZNF24	21 interacting genes: ABI3BP AEN APP BCAS2 BIN1 CEBPA DAB1 DMRTB1 FBXO7 IDH3A ITSN2 PKM PRPF39 QKI RBFOX2 RBPMS RPL21 SNRPA TLE5 UBC ZNHIT3
Entrez ID		9326	4154
HPRD ID		05139	07355
Ensembl ID		ENSG00000273611	ENSG00000152601
Uniprot IDs		Q15649	A0A0A0MQX8 C9JP00 Q86VM6 Q9NR56
PDB IDs		2YQQ 5L85	3D2N 3D2Q 3D2S 5U6H 5U6L 5U9B
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Nuclear Receptor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Positive Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway DNA Binding Domain Binding Nucleoplasm Positive Regulation Of Lipoprotein Transport MRNA Transcription By RNA Polymerase II Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific LBD Domain Binding MRNA Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Transcription Cis-regulatory Region Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Transcription By RNA Polymerase II Nucleus Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Monocyte Differentiation Eye Development Nuclear Steroid Receptor Activity RNA Polymerase II Transcription Regulator Complex	Regulation Of Astrocyte Differentiation RNA Processing Nucleus RNA Splicing Regulation Of Glial Cell Differentiation Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Gliogenesis MRNA Binding MRNA Processing U1 SnRNP Negative Regulation Of Cell Development Negative Regulation Of Blood Circulation Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Hemopoiesis Positive Regulation Of Glial Cell Differentiation Synaptic Vesicle Endocytosis Lipid Tube Positive Regulation Of Developmental Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Nucleic Acid Binding MRNA Metabolic Process Regulation Of MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Presynaptic Endocytosis Vesicle Dendrite Development Macrophage Differentiation Regulation Of RNA Splicing Regulation Of Neuron Differentiation RNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Amyloid Precursor Protein Catabolic Process Lipid Tube Assembly Negative Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Multicellular Organismal Process Acetylcholine Receptor Activator Activity Lipoprotein Particle
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