ACVR2B and INHBB

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ACVR2B	INHBB
Description		activin A receptor type 2B	inhibin subunit beta B
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development	Ovarian Follicle Development Defense Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Wounding Response To Insecticide Pituitary Gland Development Cell Differentiation Negative Regulation Of Hepatocyte Growth Factor Production Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Response To Gonadotropin Cellular Response To Leptin Stimulus Adhesion Of Symbiont To Host Cell Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Oocyte Development Positive Regulation Of Ovulation Cellular Response To Calcium Ion Cellular Response To CAMP Cellular Response To Interleukin-1 Cellular Response To Cholesterol Seminiferous Tubule Development Cellular Response To Thyroid Hormone Stimulus Apoptotic Signaling Pathway Cellular Response To Thyroglobulin Triiodothyronine Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Signaling by Activin Signaling by Activin Glycoprotein hormones Antagonism of Activin by Follistatin
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)	Age-related macular degeneration ( 23326517) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 22747683 27182965) Obesity ( 21552555) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 23263486 31985003)
Interacting Genes		26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1	12 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B BMPR2 CRIPTO FNTA IGSF1 INHA INHBA INHBC
Entrez ID		93	3625
HPRD ID		04106	00934
Ensembl ID		ENSG00000114739	ENSG00000163083
Uniprot IDs		Q13705	P09529
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY	7U5O
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation	Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Inhibin Binding Activin Receptor Activity Growth Factor Binding Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity, Type I Activin Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Activin Receptor Activity, Type II Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Ossification BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Signal Transduction Nodal Signaling Pathway System Development Regulation Of SMAD Protein Signal Transduction Protein Serine/threonine Kinase Activity Positive Regulation Of Osteoblast Differentiation Gastrulation With Mouth Forming Second Regulation Of Bone Mineralization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling BMP Signaling Pathway Determination Of Bilateral Symmetry Determination Of Left/right Symmetry Inhibin A Complex Protein Kinase Activity Regionalization Endothelial Cell Differentiation Cellular Response To BMP Stimulus Inhibin-betaglycan-ActRII Complex Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Kinase Activity Positive Regulation Of Erythrocyte Differentiation
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