ACVR2B and DLG1

Number of citations of the paper that reports this interaction (PubMedID 23722234)
86

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ACVR2B	DLG1
Description		activin A receptor type 2B	discs large MAGUK scaffold protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding	GMP Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Kinase Binding Protein Kinase Binding Phosphatase Binding Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Nervous System Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Actin Filament Polymerization Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Membrane Raft Organization Regulation Of Myelination Regulation Of Protein Localization Protein Localization To Synapse T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Tissue Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Membrane Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)	Allergic rhinitis ( 25085501) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) PR interval ( 32439900) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1	81 interacting genes: ACTA1 ACTN2 ACVR2B ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 APC ARHGEF26 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 DSCAM EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TIAM1 TJAP1 UBASH3A UBE3A WAS WNT3A
Entrez ID		93	1739
HPRD ID		04106	03007
Ensembl ID		ENSG00000114739	ENSG00000075711
Uniprot IDs		Q13705	A0A0C4DFT3 A0A590UJ08 A0A590UJ68 A0A590UJD9 A0A590UJX2 A0A590UK48 A0A590UKA8 B4DF78 Q12959
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY	1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69 7PC3 8CN1 8CN3
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation	Synapse Glutamatergic Synapse Plasma Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Metal Ion Transport PDZ Domain Binding Regulation Of Membrane Potential Monoatomic Ion Channel Complex Postsynaptic Density Membrane Monoatomic Cation Transport Monoatomic Ion Transport Regulation Of Monoatomic Ion Transport Dendritic Spine Dendrite Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Voltage-gated Potassium Channel Complex System Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Inorganic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Regulation Of System Process Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Transmembrane Transport Cell Projection Monoatomic Ion Channel Activity Neuron Projection Postsynaptic Membrane Nervous System Process Positive Regulation Of Synaptic Transmission Action Potential Regulation Of Multicellular Organismal Process Potassium Ion Transmembrane Transport Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Potassium Ion Transport Membrane Trans-synaptic Signaling Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Cell-cell Junction Modulation Of Excitatory Postsynaptic Potential Signal Transduction Axon Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?