ACVR2B and GDF2

Number of citations of the paper that reports this interaction (PubMedID 22718755)
36

Data Source:
BioGRID (pull down)

		ACVR2B	GDF2
Description		activin A receptor type 2B	growth differentiation factor 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding	Cytokine Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bicellular Tight Junction Assembly
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Signaling by BMP
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1	6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG
Entrez ID		93	2658
HPRD ID		04106	05492
Ensembl ID		ENSG00000114739	ENSG00000263761
Uniprot IDs		Q13705	B2RC63 Q9UK05
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY	1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05 9DPM 9DPN 9DPO 9DPP 9DPQ 9DPR 9DPS 9DPT 9DPU 9DPV 9DPW 9DPX
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation	Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding BMP Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Endothelial Cell Differentiation Cellular Response To BMP Stimulus Venous Blood Vessel Development Positive Regulation Of Bone Mineralization Growth Factor Binding Activin Receptor Complex Activin Receptor Activity, Type I Lymphatic Endothelial Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regionalization Regulation Of Bone Mineralization Cellular Response To Growth Factor Stimulus Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Response To Growth Factor Gastrulation With Mouth Forming Second Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Regulation Of Ossification Pattern Specification Process Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Regulation Of Osteoblast Differentiation Protein Kinase Activity Positive Regulation Of Developmental Process Receptor Complex Blood Vessel Remodeling Animal Organ Development Regulation Of Multicellular Organismal Development Kinase Activity Anatomical Structure Morphogenesis Artery Development Gastrulation Regulation Of Cell Differentiation
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