ACVR2B and SNX6

Number of citations of the paper that reports this interaction (PMID 11279102)
30

Data Source:
HPRD (in vitro, in vivo)

		ACVR2B	SNX6
Gene Name		activin A receptor, type IIB	sorting nexin 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Intracellular Nucleus Cytoplasm Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Membrane Retromer Complex Early Endosome Membrane Tubular Endosome
	Molecular Function	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding	Protein Binding Dynactin Binding Phosphatidylinositol Binding Protein Homodimerization Activity
	Biological Process	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye	Intracellular Protein Transport Endocytosis Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Vesicle Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Transcription, DNA-templated Regulation Of Histamine Secretion By Mast Cell
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1	22 interactors: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 DISC1 EGFR INSR LEPR NDEL1 PDGFRA PIM1 SNX1 SNX2 SNX4 TGFBR1 TGFBR2 TNIK TPT1
Entrez ID		93	58533
HPRD ID		04106	12086
Ensembl ID		ENSG00000114739	ENSG00000129515
Uniprot IDs		Q13705	B4DJS7 Q9UNH7
PDB IDs		2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process	Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Signal Transduction By Phosphorylation Regulation Of Signaling Developmental Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Protein Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Anatomical Structure Development Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Multicellular Organismal Development Regulation Of Phosphorylation Activation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Anatomical Structure Morphogenesis Regulation Of Phosphorus Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Differentiation Cellular Protein Modification Process Cellular Response To Growth Factor Stimulus Regulation Of Metabolic Process Sensory Organ Development Camera-type Eye Development Response To Growth Factor Positive Regulation Of Signal Transduction Retina Vasculature Development In Camera-type Eye Eye Development Phosphate-containing Compound Metabolic Process Protein Autophosphorylation Regulation Of Catalytic Activity Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Proliferation Palate Development Activin Receptor Signaling Pathway Chordate Embryonic Development Embryo Development
Tagcloud ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?		arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?