ACVR2B and GDF5

Number of citations of the paper that reports this interaction (PubMedID 8702914)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ACVR2B	GDF5
Description		activin A receptor type 2B	growth differentiation factor 5
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Activin Receptor Activity, Type II Transferase Activity Activin Receptor Activity Kinase Activator Activity Growth Factor Binding Metal Ion Binding Activin Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity BMP Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of DNA-templated Transcription Intracellular Iron Ion Homeostasis Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Pattern Specification Process Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Regulation Of Signal Transduction Insulin Secretion Negative Regulation Of Ossification Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Developmental Process Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Trophoblast Cell Migration Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Adipose Tissue Development	Chondrocyte Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Ossification Involved In Bone Remodeling Positive Regulation Of Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Chondroblast Differentiation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Apoptotic Process Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP	Molecules associated with elastic fibres
Drugs
Diseases		Heterotaxy; Situs ambiguus	Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Fibular hypoplasia and complex brachydactyly; DuPan syndrome Grebe dysplasia; Acromesomelic dysplasia Hunter-Thompson type Brachydactyly, including: Brachydactyly type C; Angel shaped phalangoepiphyseal dysplasia (ASPED)
GWAS		Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31015462 31152163) P wave duration ( 24850809)	A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Femoral neck size ( 31053729) Height ( 18391951 34270706 33713608 31562340 28552196 18391950 18391952 20189936 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Infant length ( 25281659) Intertrochanteric region size ( 31053729) Joint mobility (Beighton score) ( 27182965) Knee osteoarthritis ( 30374069 30664745) Knee pain ( 31482140) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Refractive error ( 32231278) Spine bone size ( 31053729) Trochanter size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		26 interacting genes: ACVR1B BMP10 BMP2 BMP7 CRIPTO DLG1 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NHERF2 NODAL SCRIB SNTB1 SNX1 SNX2 SNX27 SNX6 SYNJ2BP TGFBRAP1	8 interacting genes: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1
Entrez ID		93	8200
HPRD ID		04106	03092
Ensembl ID		ENSG00000114739	ENSG00000125965
Uniprot IDs		Q13705	F1T0J1 P43026
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR 7MRZ 7OLY	1WAQ 2BHK 3EVS 3QB4 5HK5 6Z3G 6Z3H 6Z3J 6Z3L 6Z3M 7ZJF 8BWL 8BWM 8BWN 8E3G
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Growth Factor Activity Activin Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine Activity Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cartilage Development Regulation Of Signaling Regulation Of Signal Transduction BMP Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Developmental Process Anatomical Structure Morphogenesis Retromer, Tubulation Complex Regulation Of Cell Communication Retromer Complex Regulation Of Cell Population Proliferation Negative Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Extracellular Space Regulation Of Cartilage Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication Signal Transduction Signaling Receptor Binding Regulation Of Multicellular Organismal Process Tissue Morphogenesis Regulation Of Cell Differentiation Morphogenesis Of A Branching Structure Cellular Response To Growth Factor Stimulus Regulation Of Locomotion Tube Morphogenesis Regulation Of Reproductive Process Response To Growth Factor Animal Organ Development Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Cartilage Development Morphogenesis Of An Epithelium Extracellular Region Nodal Signaling Pathway Mesoderm Formation	Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Receptor Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Binding Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Regionalization Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Osteoblast Differentiation Animal Organ Development Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Mitral Valve Morphogenesis Pattern Specification Process Protein Serine/threonine Kinase Activity Mesoderm Development Receptor Complex Activin Binding Protein Kinase Activity Regulation Of SMAD Protein Signal Transduction Gastrulation With Mouth Forming Second Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Atrioventricular Valve Morphogenesis Cell Differentiation Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Cellular Developmental Process Ventricular Septum Morphogenesis Regulation Of Signal Transduction Mesoderm Formation Gastrulation
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