UBE2Q2 and RNF111

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2Q2	RNF111
Gene Name		ubiquitin-conjugating enzyme E2Q family member 2	ring finger protein 111
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Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein Complex
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity	Protein Binding Zinc Ion Binding Ligase Activity SUMO Polymer Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein K48-linked Ubiquitination	Protein Polyubiquitination Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Gene Expression Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Urate levels ( 23263486)	Asperger disorder ( 21182207) Metabolite levels ( 22916037)
Protein-Protein Interactions		4 interactors: BIRC2 BIRC3 PCGF2 RNF111	39 interactors: ACTN3 ANAPC11 AXIN1 CREB1 CSNK2A1 CTBP1 DTX3L EDARADD KRTAP5-9 LCE4A LRSAM1 MARCH7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO2 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2Q2 UBE2V1 UBE2W
Entrez ID		92912	54778
HPRD ID		14294	09318
Ensembl ID		ENSG00000140367	ENSG00000157450
Uniprot IDs		C9JX13 Q8WVN8	Q6ZNA4
PDB IDs		1ZUO	2KIZ
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Protein Ubiquitination Regulation Of Necrotic Cell Death Necroptotic Process Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Protein Heterooligomerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Death Regulation Of Signaling Protein Polyubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Monoubiquitination	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Protein Monoubiquitination Negative Regulation Of Biosynthetic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Metabolic Process Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition TRIF-dependent Toll-like Receptor Signaling Pathway
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