UBE2Q2 and PCGF2

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2Q2	PCGF2
Gene Name		ubiquitin-conjugating enzyme E2Q family member 2	polycomb group ring finger 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nuclear Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein K48-linked Ubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Anterior/posterior Pattern Specification Protein Ubiquitination Histone Acetylation Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Urate levels ( 23263486)
Protein-Protein Interactions		4 interactors: BIRC2 BIRC3 PCGF2 RNF111	23 interactors: ABHD6 CBX6 CBX7 CBX8 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		92912	7703
HPRD ID		14294	10621
Ensembl ID		ENSG00000140367	ENSG00000056661
Uniprot IDs		C9JX13 Q8WVN8	P35227
PDB IDs		1ZUO
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Protein Ubiquitination Regulation Of Necrotic Cell Death Necroptotic Process Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Necrotic Cell Death TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Defense Response To Virus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Toll-like Receptor Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Protein Heterooligomerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Death Regulation Of Signaling Protein Polyubiquitination Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Signal Transduction Regulation Of Protein Monoubiquitination	Histone Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Chromatin Modification Chromatin Organization Protein Polyubiquitination Histone Modification Chromosome Organization Protein K48-linked Ubiquitination Protein Monoubiquitination Histone H2A Monoubiquitination Cellular Protein Modification Process Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Histone Monoubiquitination Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Sterol Regulatory Element Binding Protein Import Into Nucleus RNA Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Modification-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Anterior/posterior Pattern Specification Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Protein Catabolic Process Histone H2A-K119 Monoubiquitination Protein Metabolic Process Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein Catabolic Process Regulation Of Gene Expression Protein Linear Polyubiquitination Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity
Tagcloud ?			acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?			acetylase aldh1a3 belonging bipotent cbx6 ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?