UBE2Q2

Description		ubiquitin conjugating enzyme E2 Q2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31015462 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 33832965) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Triglyceride levels in HIV infection ( 33109212) Urate levels ( 23263486 31985003) Urate levels in obese individuals ( 25811787)
Interacting Genes		11 interacting genes: BIRC2 BIRC3 HECTD3 ITCH MDM2 PCGF2 RC3H2 RNF111 RNF31 UBA1 UBC
Entrez ID		92912
HPRD ID		14294
Ensembl ID		ENSG00000140367
Uniprot IDs		Q8WVN8
PDB IDs		1ZUO
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Necroptotic Process Ubiquitin-protein Transferase Activity Regulation Of Programmed Necrotic Cell Death Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Transferase Activity Catabolic Process Protein Metabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification CD40 Receptor Complex Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Zinc Ion Binding Ligase Activity Protein-containing Complex Positive Regulation Of Post-translational Protein Modification Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Proteasomal Protein Catabolic Process Regulation Of Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Toll-like Receptor Signaling Pathway Ribonucleoprotein Complex Binding Positive Regulation Of Catabolic Process Macromolecule Metabolic Process
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