UBE2Q2 and HECTD3

Number of citations of the paper that reports this interaction (PubMedID 33607208)
0

Data Source:
BioGRID (pull down)

		UBE2Q2	HECTD3
Description		ubiquitin conjugating enzyme E2 Q2	HECT domain E3 ubiquitin protein ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Syntaxin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Protein K48-linked Ubiquitination	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 30604766 31015462 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Glomerular filtration rate ( 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gout ( 33832965) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Triglyceride levels in HIV infection ( 33109212) Urate levels ( 23263486 31985003) Urate levels in obese individuals ( 25811787)
Interacting Genes		11 interacting genes: BIRC2 BIRC3 HECTD3 ITCH MDM2 PCGF2 RC3H2 RNF111 RNF31 UBA1 UBC	17 interacting genes: BRCA1 CASP8 CASP9 CHUK HSP90AA1 PARP1 PPL RAF1 TP53 TRIOBP UBE2A UBE2C UBE2D2 UBE2D3 UBE2Q2 UBE2S ZDHHC17
Entrez ID		92912	79654
HPRD ID		14294	13383
Ensembl ID		ENSG00000140367	ENSG00000126107
Uniprot IDs		Q8WVN8	A1A4G1 B3KU34 Q5T447
PDB IDs		1ZUO
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Necroptotic Process Ubiquitin-protein Transferase Activity Regulation Of Programmed Necrotic Cell Death Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Proteolysis Negative Regulation Of Necroptotic Process Negative Regulation Of Programmed Necrotic Cell Death Transferase Activity Catabolic Process Protein Metabolic Process Canonical NF-kappaB Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Post-translational Protein Modification CD40 Receptor Complex Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin Binding Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Zinc Ion Binding Ligase Activity Protein-containing Complex Positive Regulation Of Post-translational Protein Modification Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Proteasomal Protein Catabolic Process Regulation Of Immune Response Non-canonical NF-kappaB Signal Transduction Regulation Of Protein Ubiquitination Negative Regulation Of CD4-positive, Alpha-beta T Cell Activation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Toll-like Receptor Signaling Pathway Ribonucleoprotein Complex Binding Positive Regulation Of Catabolic Process Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Metabolic Process Protein Polyubiquitination Ubiquitin Protein Ligase Binding Protein Modification Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Transferase Activity Macromolecule Metabolic Process Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Protein Ubiquitination Positive Regulation Of Execution Phase Of Apoptosis Protein K6-linked Ubiquitination ATP Binding Protein Modification By Small Protein Conjugation Protein-containing Complex Regulation Of Programmed Necrotic Cell Death Proteolysis Glial Cell Apoptotic Process Apoptotic Process Apoptotic Signaling Pathway Nucleotide Binding Response To Indole-3-methanol Response To Anesthetic Positive Regulation Of Ubiquitin Protein Ligase Activity Response To UV Programmed Cell Death Cell Death Mitochondrial DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Free Ubiquitin Chain Polymerization Cellular Response To Radiation Cytosol Response To Stress Proteolysis Involved In Protein Catabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Response To Cobalt Ion Protein Autoubiquitination Scaffold Protein Binding DNA Metabolic Process Response To Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response
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