G6PC3 and CCR9

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		G6PC3	CCR9
Description		glucose-6-phosphatase catalytic subunit 3	C-C motif chemokine receptor 9
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Glucose-6-phosphatase Activity Hydrolase Activity	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Gluconeogenesis Glucose-6-phosphate Transport Glucose 6-phosphate Metabolic Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Severe congenital neutropenia type 4 (G6PC3) Gluconeogenesis	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs			Vercirnon
Diseases		Neutropenia, severe congenital 4, autosomal recessive; G6PC3 deficiency; Darsun syndrome
GWAS		Bipolar disorder ( 31043756) Glycated hemoglobin levels ( 24244560) Height ( 33713608)	Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		4 interacting genes: CCR9 CNKSR1 GPR37 HTR2B	19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE
Entrez ID		92579	10803
HPRD ID		13556	09200
Ensembl ID		ENSG00000141349	ENSG00000173585
Uniprot IDs		A0A8Q3SIG5 K7EJC5 Q9BUM1	B2R734 P51686
PDB IDs			5LWE
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Calcium-mediated Signaling CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Phospholipase C-activating Serotonin Receptor Signaling Pathway Locomotion Dopamine Biosynthetic Process Serotonin Binding Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Gamma-delta T Cell Differentiation Serotonin Receptor Activity Neural Crest Cell Differentiation G Protein-coupled Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Signal Transduction Catecholamine Biosynthetic Process Positive Regulation Of MAPK Cascade Dendrite Neuropeptide Receptor Activity Plasma Membrane Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Gamma-delta T Cell Activation Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cardiac Muscle Hypertrophy Neuropeptide Binding Muscle Hypertrophy Peptide Binding G-protein Alpha-subunit Binding CGMP-mediated Signaling Dopamine Metabolic Process Vasoconstriction Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Regulation Of MAPK Cascade Cell Surface Regulation Of Phospholipid Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development	Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity
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