CCR9 and TTYH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	TTYH1
Description		C-C motif chemokine receptor 9	tweety family member 1
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane Membrane Smooth Endoplasmic Reticulum Membrane Filopodium Membrane Filopodium Tip Chloride Channel Complex Synapse
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Volume-sensitive Anion Channel Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Iron Ion Transmembrane Transporter Activity Calcium Ion Binding Protein Binding Volume-sensitive Chloride Channel Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Mitotic Cell Cycle Cell Morphogenesis Monoatomic Ion Transport Chloride Transport Iron Ion Transport Cell Adhesion Notch Signaling Pathway Gene Expression L-glutamate Transmembrane Transport Neurogenesis Cell-substrate Adhesion Monoatomic Ion Transmembrane Transport Iron Ion Transmembrane Transport Filopodium Assembly Stem Cell Differentiation Stem Cell Proliferation Cell-cell Adhesion Chloride Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Vercirnon
Diseases
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Blood trace element (Se levels) ( 23720494) Idiopathic pulmonary fibrosis ( 29066090)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	6 interacting genes: CCR9 DRD2 DSCR9 GPR37 HTR6 TMEM60
Entrez ID		10803	57348
HPRD ID		09200	12043
Ensembl ID		ENSG00000173585	ENSG00000167614
Uniprot IDs		B2R734 P51686	Q9H313
PDB IDs		5LWE	7P5J
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	G Protein-coupled Receptor Activity Telencephalon Cell Migration G Protein-coupled Receptor Signaling Pathway Forebrain Cell Migration Catecholamine Metabolic Process Dopamine Metabolic Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Biogenic Amine Metabolic Process Amine Metabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Dendrite G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Prosaposin Receptor Activity Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Dopamine Binding Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Negative Regulation Of Dephosphorylation Positive Regulation Of Renal Sodium Excretion Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Branching Morphogenesis Of A Nerve Negative Regulation Of Dopamine Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Dopamine Metabolic Process Adenylate Cyclase-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Regulation Of Synapse Structural Plasticity Regulation Of Renal Sodium Excretion Interneuron Migration From The Subpallium To The Cortex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Dopamine Receptor Signaling Pathway Locomotion Involved In Locomotory Behavior Negative Regulation Of Synaptic Transmission, Glutamatergic Response To Histamine Regulation Of Dopamine Receptor Signaling Pathway Catecholamine Uptake Dopamine Uptake
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