CCR9 and KDELR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	KDELR1
Description		C-C motif chemokine receptor 9	KDEL endoplasmic reticulum protein retention receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Membrane Transport Vesicle COPI-coated Vesicle Membrane Cytoplasmic Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	KDEL Sequence Binding Protein Binding ER Retention Sequence Binding
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Protein Retention In ER Lumen Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Vesicle-mediated Transport T Cell Differentiation T Cell Apoptotic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Vercirnon
Diseases
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	12 interacting genes: ARF1 ARFGAP1 CCR9 COPB1 DLG2 DLG3 F2RL1 GPR35 KRT34 LIG4 PRKACA SEC23B
Entrez ID		10803	10945
HPRD ID		09200	00569
Ensembl ID		ENSG00000173585	ENSG00000105438
Uniprot IDs		B2R734 P51686	P24390
PDB IDs		5LWE
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	Intracellular Protein Transport Neuromuscular Junction Protein Transport Regulation Of Endocytosis Intracellular Protein Localization Establishment Of Protein Localization Chemokine Receptor Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Ionotropic Glutamate Receptor Binding Cellular Localization Magnesium Ion Binding Regulation Of Biological Quality Mitotic Cleavage Furrow Ingression Regulation Of Vesicle-mediated Transport Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Establishment Of Integrated Proviral Latency Protein Localization To Synapse Intracellular Transport Cleavage Furrow Ingression Retrograde Axonal Protein Transport Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Proteinase-activated Receptor Activity Mononuclear Cell Differentiation Positive Regulation Of Phagocytosis T Cell Activation Positive Regulation Of Eosinophil Degranulation Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Chemokine-mediated Signaling Pathway Establishment Of Viral Latency Neuron Projection Protein Localization To Cell Junction Positive Regulation Of Glomerular Filtration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Renin Secretion Into Blood Stream Leukocyte Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Kinase Binding Regulation Of Phagocytosis Establishment Of Localization In Cell Postsynaptic Density Membrane
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