CCR9 and TMC6

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	TMC6
Description		C-C motif chemokine receptor 9	transmembrane channel like 6
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Golgi Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Nuclear Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding Mechanosensitive Monoatomic Ion Channel Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Intracellular Zinc Ion Homeostasis Monoatomic Ion Transmembrane Transport Protein Stabilization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Neutrophil degranulation
Drugs		Vercirnon
Diseases			Epidermodysplasia verruciformis
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Glycated hemoglobin levels ( 31213470 34059833 29170429 28887542) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 32327693) hemolysis of donated blood (cold-storage) ( 34014839) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494 29403010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 27863252 29403010 32888494) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum uric acid levels ( 29559957)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	3 interacting genes: CCR9 ZBTB2 ZDHHC17
Entrez ID		10803	11322
HPRD ID		09200	08386
Ensembl ID		ENSG00000173585	ENSG00000141524
Uniprot IDs		B2R734 P51686	A0A8V8TLY1 Q7Z403
PDB IDs		5LWE
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Differentiation Gamma-delta T Cell Activation Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Protein Lipidation
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