CCR9 and TRPM4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	TRPM4
Description		C-C motif chemokine receptor 9	transient receptor potential cation channel subfamily M member 4
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Nucleoplasm Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Sodium Channel Complex Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Nucleotide Binding Monoatomic Ion Channel Activity Calcium-activated Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Metal Ion Binding Metal Ion Transmembrane Transporter Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Adaptive Immune Response Immune System Process Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Protein Sumoylation Calcium-mediated Signaling Metal Ion Transport Negative Regulation Of Bone Mineralization Monoatomic Ion Transmembrane Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Vasoconstriction Protein Homotetramerization Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To ATP Membrane Depolarization During AV Node Cell Action Potential Membrane Depolarization During Purkinje Myocyte Cell Action Potential Membrane Depolarization During Bundle Of His Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Canonical Wnt Signaling Pathway Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Sodium Ion Import Across Plasma Membrane Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Adipose Tissue Development Positive Regulation Of Regulation Of Vascular Associated Smooth Muscle Cell Membrane Depolarization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	TRP channels Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs		Vercirnon	Glyburide
Diseases
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	1 interacting genes: CCR9
Entrez ID		10803	54795
HPRD ID		09200	09502
Ensembl ID		ENSG00000173585	ENSG00000130529
Uniprot IDs		B2R734 P51686	B4DIX5 Q8TD43
PDB IDs		5LWE	5WP6 6BQR 6BQV 6BWI 8RCR 8RCU 8RD9 9B8W 9B8X 9B8Y 9B8Z 9B90 9B91 9B92 9B93 9B94
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Differentiation Gamma-delta T Cell Activation Cellular Defense Response Chemokine-mediated Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration T Cell Differentiation Calcium-mediated Signaling Cell Chemotaxis
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