CCR9 and G6PC3

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	G6PC3
Description		C-C motif chemokine receptor 9	glucose-6-phosphatase catalytic subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Glucose-6-phosphatase Activity Hydrolase Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Gluconeogenesis Glucose-6-phosphate Transport Glucose 6-phosphate Metabolic Process
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Severe congenital neutropenia type 4 (G6PC3) Gluconeogenesis
Drugs		Vercirnon
Diseases			Neutropenia, severe congenital 4, autosomal recessive; G6PC3 deficiency; Darsun syndrome
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Bipolar disorder ( 31043756) Glycated hemoglobin levels ( 24244560) Height ( 33713608)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	4 interacting genes: CCR9 CNKSR1 GPR37 HTR2B
Entrez ID		10803	92579
HPRD ID		09200	13556
Ensembl ID		ENSG00000173585	ENSG00000141349
Uniprot IDs		B2R734 P51686	A0A8Q3SIG5 K7EJC5 Q9BUM1
PDB IDs		5LWE
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Calcium-mediated Signaling CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Phospholipase C-activating Serotonin Receptor Signaling Pathway Locomotion Dopamine Biosynthetic Process Serotonin Binding Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Gamma-delta T Cell Differentiation Serotonin Receptor Activity Neural Crest Cell Differentiation G Protein-coupled Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Signal Transduction Catecholamine Biosynthetic Process Positive Regulation Of MAPK Cascade Dendrite Neuropeptide Receptor Activity Plasma Membrane Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Gamma-delta T Cell Activation Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cardiac Muscle Hypertrophy Neuropeptide Binding Muscle Hypertrophy Peptide Binding G-protein Alpha-subunit Binding CGMP-mediated Signaling Dopamine Metabolic Process Vasoconstriction Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Regulation Of MAPK Cascade Cell Surface Regulation Of Phospholipid Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development
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