G6PC3 and GPR37

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		G6PC3	GPR37
Description		glucose-6-phosphatase catalytic subunit 3	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Membrane Dendrite Cell Projection Receptor Complex Synapse
	Molecular Function	Glucose-6-phosphatase Activity Hydrolase Activity	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity PDZ Domain Binding Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Gluconeogenesis Glucose-6-phosphate Transport Glucose 6-phosphate Metabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Dendrite Development Locomotion Involved In Locomotory Behavior Cellular Response To Reactive Oxygen Species Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process
Pathways		Severe congenital neutropenia type 4 (G6PC3) Gluconeogenesis	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases		Neutropenia, severe congenital 4, autosomal recessive; G6PC3 deficiency; Darsun syndrome
GWAS		Bipolar disorder ( 31043756) Glycated hemoglobin levels ( 24244560) Height ( 33713608)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 26237428 32341527) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: CCR9 CNKSR1 GPR37 HTR2B	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		92579	2861
HPRD ID		13556	03992
Ensembl ID		ENSG00000141349	ENSG00000170775
Uniprot IDs		A0A8Q3SIG5 K7EJC5 Q9BUM1	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Calcium-mediated Signaling CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Phospholipase C-activating Serotonin Receptor Signaling Pathway Locomotion Dopamine Biosynthetic Process Serotonin Binding Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Gamma-delta T Cell Differentiation Serotonin Receptor Activity Neural Crest Cell Differentiation G Protein-coupled Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Signal Transduction Catecholamine Biosynthetic Process Positive Regulation Of MAPK Cascade Dendrite Neuropeptide Receptor Activity Plasma Membrane Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Gamma-delta T Cell Activation Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cardiac Muscle Hypertrophy Neuropeptide Binding Muscle Hypertrophy Peptide Binding G-protein Alpha-subunit Binding CGMP-mediated Signaling Dopamine Metabolic Process Vasoconstriction Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Regulation Of MAPK Cascade Cell Surface Regulation Of Phospholipid Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development	Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway COPII-coated ER To Golgi Transport Vesicle Regulation Of Catecholamine Secretion Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dendrite ERAD Pathway Synaptic Transmission, Dopaminergic Regulation Of Autophagy Of Mitochondrion Cell Communication Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chemical Synaptic Transmission Regulation Of Membrane Potential Regulation Of Dopamine Secretion Cell-cell Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Signal Transduction Trans-synaptic Signaling Signaling Regulation Of Amine Transport Synaptic Signaling Modulation Of Chemical Synaptic Transmission Neuron-glial Cell Signaling Response To Psychosocial Stress Cellular Localization Synapse Positive Regulation Of Autophagy Of Mitochondrion Golgi Membrane Negative Regulation Of Dopamine Secretion Transmembrane Transport Response To Endoplasmic Reticulum Stress G Protein-coupled Receptor Binding Cellular Response To Topologically Incorrect Protein Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Glucose-6-phosphate Transport Volume-sensitive Chloride Channel Activity Establishment Of Localization In Cell Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Neurotransmitter Uptake Volume-sensitive Anion Channel Activity Regulation Of Synaptic Transmission, GABAergic Intracellular Transport Plasma Membrane Calcium Ion Transmembrane Import Into Cytosol Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Mitochondrial Fusion
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