G6PC3 and HTR2B

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		G6PC3	HTR2B
Description		glucose-6-phosphatase catalytic subunit 3	5-hydroxytryptamine receptor 2B
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex
	Molecular Function	Glucose-6-phosphatase Activity Hydrolase Activity	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Gluconeogenesis Glucose-6-phosphate Transport Glucose 6-phosphate Metabolic Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Severe congenital neutropenia type 4 (G6PC3) Gluconeogenesis	Serotonin receptors G alpha (q) signalling events
Drugs			Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases		Neutropenia, severe congenital 4, autosomal recessive; G6PC3 deficiency; Darsun syndrome
GWAS		Bipolar disorder ( 31043756) Glycated hemoglobin levels ( 24244560) Height ( 33713608)	Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		4 interacting genes: CCR9 CNKSR1 GPR37 HTR2B	27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1
Entrez ID		92579	3357
HPRD ID		13556	03077
Ensembl ID		ENSG00000141349	ENSG00000135914
Uniprot IDs		A0A8Q3SIG5 K7EJC5 Q9BUM1	P41595
PDB IDs			4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Prosaposin Receptor Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Calcium-mediated Signaling CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Positive Regulation Of Dopamine Metabolic Process Locomotion Involved In Locomotory Behavior Phospholipase C-activating Serotonin Receptor Signaling Pathway Locomotion Dopamine Biosynthetic Process Serotonin Binding Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway Gamma-delta T Cell Differentiation Serotonin Receptor Activity Neural Crest Cell Differentiation G Protein-coupled Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Signal Transduction Catecholamine Biosynthetic Process Positive Regulation Of MAPK Cascade Dendrite Neuropeptide Receptor Activity Plasma Membrane Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Gamma-delta T Cell Activation Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Cardiac Muscle Hypertrophy Neuropeptide Binding Muscle Hypertrophy Peptide Binding G-protein Alpha-subunit Binding CGMP-mediated Signaling Dopamine Metabolic Process Vasoconstriction Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Regulation Of MAPK Cascade Cell Surface Regulation Of Phospholipid Metabolic Process G Protein-coupled Peptide Receptor Activity Dendrite Development	Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway
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