CCR9 and DGAT1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	DGAT1
Description		C-C motif chemokine receptor 9	diacylglycerol O-acyltransferase 1
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Identical Protein Binding Retinol O-fatty-acyltransferase Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Retinoid Metabolic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Lipid Storage Very-low-density Lipoprotein Particle Assembly Long-chain Fatty-acyl-CoA Metabolic Process Retinol Metabolic Process Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Fatty Acid Homeostasis
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Acyl chain remodeling of DAG and TAG Neutrophil degranulation Triglyceride biosynthesis
Drugs		Vercirnon
Diseases
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Dupuytren's disease ( 28886342) Fasting glucose ( 34059833)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	3 interacting genes: CCR9 CD1A GABRA4
Entrez ID		10803	8694
HPRD ID		09200	05360
Ensembl ID		ENSG00000173585	ENSG00000185000
Uniprot IDs		B2R734 P51686	O75907
PDB IDs		5LWE	6VP0 6VYI 6VZ1 8ESM 8ETM
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	Antigen Processing And Presentation, Endogenous Lipid Antigen Via MHC Class Ib Exogenous Lipid Antigen Binding Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Endogenous Lipid Antigen Binding GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Protein Retention In ER Lumen Lipopeptide Binding GPI Anchor Binding External Side Of Plasma Membrane Benzodiazepine Receptor Activity Gamma-delta T Cell Differentiation Maintenance Of Protein Localization In Endoplasmic Reticulum GABA-A Receptor Activity GABA-A Receptor Complex GABA-gated Chloride Ion Channel Activity Inhibitory Synapse Assembly Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Gamma-delta T Cell Activation Antigen Processing And Presentation Of Endogenous Antigen Gamma-aminobutyric Acid Signaling Pathway Postsynaptic Specialization Membrane GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Dendrite Membrane Synaptic Transmission, GABAergic Positive Regulation Of T Cell Mediated Cytotoxicity Extracellular Ligand-gated Monoatomic Ion Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
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