CCR9 and SPNS1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CCR9	SPNS1
Description		C-C motif chemokine receptor 9	SPNS lysolipid transporter 1, lysophospholipid
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Mitochondrion Mitochondrial Inner Membrane Lysosome Lysosomal Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Binding Transmembrane Transporter Activity
	Biological Process	CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Chemotaxis Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Lipid Transport Phospholipid Efflux Regulation Of Lysosomal Lumen PH Lysophospholipid Transport Transmembrane Transport
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Vercirnon
Diseases
GWAS		Celiac disease ( 20190752) Liver enzyme levels (alkaline phosphatase) ( 33972514) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Educational attainment ( 25201988)
Interacting Genes		19 interacting genes: ADGRG1 AIG1 CCL25 CD81 DGAT1 G6PC3 HLA-A KDELR1 NEU1 OSTC RHBDD2 SAP130 SCAMP4 SPNS1 TMC6 TRPM4 TSPAN7 TTYH1 YWHAE	8 interacting genes: ADORA2A BCL2 BCL2L1 BDKRB2 CCR8 CCR9 CHRM5 HTR2C
Entrez ID		10803	83985
HPRD ID		09200	11599
Ensembl ID		ENSG00000173585	ENSG00000169682
Uniprot IDs		B2R734 P51686	Q9H2V7
PDB IDs		5LWE	9BOI
Enriched GO Terms of Interacting Partners?		Regulation Of T Cell Cytokine Production Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Regulation Of T Cell Mediated Immunity	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Dendritic Cell Apoptotic Process BH3 Domain Binding Regulation Of Mitochondrial Membrane Potential Defense Response Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Apoptotic Signaling Pathway Signal Transduction Regulation Of Biological Quality Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Anoikis Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Programmed Cell Death Involved In Cell Development Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Release Of Cytochrome C From Mitochondria Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Chemokine Receptor Activity C-C Chemokine Binding C-C Chemokine Receptor Activity Regulation Of Anoikis Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Behavioral Fear Response Behavioral Defense Response Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phospholipid Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Channel Activity Fear Response Blood Circulation Regulation Of Neuron Apoptotic Process Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Vascular Permeability Epithelial Cell Apoptotic Process Ovarian Follicle Development Leukocyte Apoptotic Process Cellular Defense Response Response To Gamma Radiation Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
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