MAPK11 and DOT1L

Number of citations of the paper that reports this interaction (PubMedID 38270553)
0

Data Source:
BioGRID (enzymatic study)

		MAPK11	DOT1L
Description		mitogen-activated protein kinase 11	DOT1 like histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity Protein Binding Methyltransferase Activity Transferase Activity Histone H3K79 Methyltransferase Activity Histone Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Histone H3 Methyltransferase Activity Histone H3K79 Trimethyltransferase Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To UV-B Cellular Senescence Cellular Response To Virus NLRP1 Inflammasome Complex Assembly	DNA Damage Checkpoint Signaling DNA Repair Chromatin Organization Gene Expression Heterochromatin Formation Subtelomeric Heterochromatin Formation Telomere Organization Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Cycle Regulation Of Transcription Regulatory Region DNA Binding
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	PKMTs methylate histone lysines
Drugs		Minocycline KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)	Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 23563607 25282103 18391950 28552196) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878 30578418 30487518 29403010 26390057 27618448) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 30487518 27618448) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DOT1L DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	6 interacting genes: H3-4 MAPK11 MLLT10 MYCN STAT1 UBE3C
Entrez ID		5600	84444
HPRD ID		04208	10455
Ensembl ID		ENSG00000185386	ENSG00000104885
Uniprot IDs		Q15759	A0A8I5QL06 Q8TEK3
PDB IDs		3GC8 3GC9 3GP0 8YGW	1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN 7BWD 7EDP 7S7E 7S7F 7XCR 7XCT
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mitogen-activated Protein Kinase P38 Binding Regulation Of Growth Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Growth Chromatin Binding Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Enzyme Binding Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Regulation Of Multicellular Organism Growth Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Stress Mitogen-activated Protein Kinase Binding Regulation Of Developmental Process Chromatin Remodeling Cellular Response To Anisomycin Nucleus Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Microglial Cell Activation Response To Anisomycin Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Main Axon Liver Development	Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Erythrocyte Differentiation Regulation Of Erythrocyte Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Autosome Genomic Imprinting Regulation Of Cell Development DNA Binding Cell Population Proliferation Regulation Of Epithelial Cell Differentiation Regulation Of Cell Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation NLRP1 Inflammasome Complex Assembly Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Nephron Tubule Epithelial Cell Differentiation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Histone Binding Interleukin-7-mediated Signaling Pathway ISGF3 Complex Negative Regulation By Virus Of Viral Protein Levels In Host Cell Interleukin-27-mediated Signaling Pathway Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal Cell Differentiation Involved In Kidney Development Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Negative Regulation Of Developmental Process Nucleoplasm Regulation Of Inner Ear Auditory Receptor Cell Differentiation Cell Proliferation Involved In Kidney Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Nephron Tubule Epithelial Cell Differentiation Protein K29-linked Ubiquitination Regulation Of Developmental Process Negative Regulation Of Astrocyte Differentiation Cellular Response To UV-B Type II Interferon-mediated Signaling Pathway Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process MAP Kinase Activity Positive Regulation Of Gene Expression
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