MAPK11 and MBP

Number of citations of the paper that reports this interaction (PubMedID 17906618)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MAPK11	MBP
Description		mitogen-activated protein kinase 11	myelin basic protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Internode Region Of Axon Cell Projection Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protease Binding Protein Binding Calmodulin Binding Lipid Binding Structural Constituent Of Myelin Sheath
	Biological Process	MAPK Cascade Osteoblast Differentiation Positive Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction P38MAPK Cascade Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Protein Maturation Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Pyroptotic Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To UV-B Cellular Senescence Cellular Response To Virus NLRP1 Inflammasome Complex Assembly	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Minocycline KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)	Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)
Interacting Genes		28 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DOT1L DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	83 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEIL3 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSC1 TSSK6 ULK1
Entrez ID		5600	4155
HPRD ID		04208	01158
Ensembl ID		ENSG00000185386	ENSG00000197971
Uniprot IDs		Q15759	P02686
PDB IDs		3GC8 3GC9 3GP0 8YGW	1BX2 1FV1 1HQR 1K2D 1YMM 1ZGL
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Mitogen-activated Protein Kinase P38 Binding Regulation Of Growth Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Developmental Growth Chromatin Binding Response To Metal Ion Negative Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Enzyme Binding Regulation Of Neuron Apoptotic Process Regulation Of Signal Transduction Positive Regulation Of Biosynthetic Process Positive Regulation Of Developmental Process Regulation Of Multicellular Organism Growth Signal Transduction In Response To DNA Damage Positive Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Response To Stress Mitogen-activated Protein Kinase Binding Regulation Of Developmental Process Chromatin Remodeling Cellular Response To Anisomycin Nucleus Positive Regulation Of RNA Metabolic Process Protein Serine/threonine Phosphatase Activity Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Microglial Cell Activation Response To Anisomycin Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Leukocyte Activation Involved In Inflammatory Response Nucleoplasm Negative Regulation Of RNA Biosynthetic Process Main Axon Liver Development	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Kinase Activity Kinase Activity Protein Phosphorylation ATP Binding Phosphorylation Transferase Activity Nucleotide Binding Intracellular Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process MAPK Cascade Protein Metabolic Process Response To Stress Intracellular Signaling Cassette Cellular Response To Stress Peptidyl-serine Phosphorylation Macromolecule Metabolic Process Protein Autophosphorylation Signal Transduction MAP Kinase Activity Regulation Of Cell Differentiation Regulation Of Intracellular Signal Transduction Positive Regulation Of Biosynthetic Process Regulation Of Developmental Process Regulation Of MAPK Cascade Nucleus Positive Regulation Of Developmental Process Magnesium Ion Binding Positive Regulation Of Intracellular Signal Transduction DNA Damage Response RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cell Development Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Peptidyl-threonine Phosphorylation Nucleoplasm Stress-activated MAPK Cascade Regulation Of Gene Expression Stress-activated Protein Kinase Signaling Cascade Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Cell Surface Receptor Signaling Pathway
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